The Naturally Attenuated Kunjin Strain of West Nile Virus Shows Enhanced Sensitivity to the Host Type I Interferon Response
The Naturally Attenuated Kunjin Strain of West Nile Virus Shows Enhanced Sensitivity to the Host Type I Interferon Response
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DOI：
10.1128/jvi.00232-11
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发表时间：
2011-06-01
影响因子：
5.4
通讯作者：
Diamond, Michael S.
中科院分区：
文献类型：
--
作者：
Daffis, Stephane;Lazear, Helen M.;Diamond, Michael S.
导致西尼罗河病毒（WNV）天然存在的非致病性毒株昆金毒株（WNVKUN）减毒的宿主决定因素仍然未知。在这里，我们发现，与高致病性北美菌株相比，WNVKUN 对 I 型干扰素的抗病毒作用表现出增强的敏感性。我们的研究表明，在缺乏特定干扰素调节因子 (IRF) 或常见 I 型干扰素受体的细胞和小鼠中，WNVKUN 的毒力可以恢复。因此，WNVKUN 主要通过 I 型干扰素和 IRF-3 依赖性机制的增强限制来减弱。
The host determinants that contribute to attenuation of the naturally occurring nonpathogenic strain of West Nile virus (WNV), the Kunjin strain (WNVKUN), remain unknown. Here, we show that compared to a highly pathogenic North American strain, WNVKUN exhibited an enhanced sensitivity to the antiviral effects of type I interferon. Our studies establish that the virulence of WNVKUN can be restored in cells and mice deficient in specific interferon regulatory factors (IRFs) or the common type I interferon receptor. Thus, WNVKUN is attenuated primarily through its enhanced restriction by type I interferon-and IRF-3-dependent mechanisms.