Interleukin-4 and interleukin-13: their similarities and discrepancies.
Interleukin-4 and interleukin-13: their similarities and discrepancies.
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DOI：
10.3109/08830189809084486
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发表时间：
1998-01-01
影响因子：
5
通讯作者：
Banchereau, J
中科院分区：
文献类型：
--
作者：
Chomarat, P;Banchereau, J
白细胞介素-4（IL-4）和与之密切相关的细胞因子白细胞介素-13（IL-13）在B淋巴细胞、单核细胞、树突状细胞和成纤维细胞上具有许多生物学和免疫调节功能。IL-4和IL-13基因都位于5号染色体上的相同附近，并且在它们各自的启动子中显示相同的主要调控序列，从而解释了它们对活化的T细胞和肥大细胞的限制性分泌模式。IL-4和IL-13受体是多聚体的，并且共享至少一个称为IL-4 R α的共同链。在IL-4和IL-13受体复合物的描述中取得的最新进展已经证明存在两种类型的IL-4受体：一种由IL-4 R α和γ c链构成，第二种由IL-4 R α和IL-13 R α 1构成并且能够抑制IL-4和IL-13信号。特异性IL-13受体是由IL-4 R α和IL-13 R α 2之间或两个IL-13 R α之间的结合产生的。此外，还描述了IL-4和IL-13信号转导的相似性，从而解释了IL-4和IL-13诱导的生物活性（如抗体产生和炎症的调节）的显著重叠。然而，IL-4对2型辅助性T淋巴细胞的受限表达以及由于T淋巴细胞上缺乏IL-13受体而导致IL-13不能调节T细胞分化代表了这些细胞因子之间的主要差异。这将表明，虽然IL-4和IL-13共享大量特性，但也存在精确的调节机制以保证其独特的功能。
Interleukin-4 (IL-4) and the closely related cytokine, interleukin-13 (IL-13) share many biological and immunoregulatory functions on B lymphocytes, monocytes, dendritic cells and fibroblasts. Both IL-4 and IL-13 genes are located in the same vicinity on chromosome 5 and display identical major regulatory sequences in their respective promoters, thus explaining their restricted secretion pattern to activated T cells and mast cells. The IL-4 and IL-13 receptors are multimeric and share at least one common chain called IL-4R alpha. Recent progress made in the description of IL-4 and IL-13 receptor complex have demonstrated the existence of two types of IL-4 receptors: one constituted by the IL-4R alpha and the gamma c chain, and a second constituted by the IL-4 R alpha and the IL-13R alpha 1 and able to transduce both IL-4 and IL-13 signals. Specific IL-13 receptors are results from the association between the IL-4R alpha and the IL-13R alpha 2 or between two IL-13R alpha. Furthermore, similarities in IL-4 and IL-13 signal transduction have been also described, thus explaining the striking overlapping of IL-4- and IL-13-induced biological activities such as regulation of antibody production and inflammation. However, the restricted expression of IL-4 to type 2 helper T lymphocytes as well as the inability of IL-13 to regulate T cell differentiation due to a lack of IL-13 receptors on T lymphocytes represent the major differences between these cytokines. This would indicate that although IL-4 and IL-13 share a large number of properties, precise mechanisms of regulation are also present to guarantee their distinct functions.