Running wheel accessibility affects the regional electroencephalogram during sleep in mice.
Running wheel accessibility affects the regional electroencephalogram during sleep in mice.
复制标题
跑轮的可达性会影响小鼠睡眠期间的区域脑电图。
DOI：
10.1093/cercor/bhi110
复制
发表时间：
2006
期刊：
影响因子：
3.7
通讯作者：
I. Tobler
中科院分区：
文献类型：
--
作者：
V. Vyazovskiy;Guido Ruijgrok;T. Deboer;I. Tobler
在提供了几个星期的跑轮的小鼠身上，研究了睡眠稳态的区域性方面。连续3天记录初级运动(额叶)和躯体感觉皮质(顶叶)脑电频谱。在一天(第二天)，车轮被锁定以防止运行。在入睡后2小时内，车轮跑与慢波活动额顶比(脑电功率0.75~4.0赫兹)呈负相关(r=-0.60；P<；0.01)。在第2天，非快速眼动睡眠的额叶脑电功率(2.25-8.0赫兹)超过了前一天的水平，这表明用多样化的行为取代了跑轮子的行为引起了更明显的区域脑电差异。入睡前2 h低频区(0.75~1.0 Hz)的额顶功率比与前一次觉醒时间呈正相关(r=0.6 4，P<0.001.0 5)，而Delta频段剩余频率(1.2 5~4.0 Hz)的功率比与觉醒无关。数据表明，在小鼠中，与猫和人类所描述的缓慢振荡相对应的较低频率的脑电功率与局部睡眠动态平衡有关。
Regional aspects of sleep homeostasis were investigated in mice provided with a running wheel for several weeks. Electroencephalogram (EEG) spectra of the primary motor (frontal) and somatosensory cortex (parietal) were recorded for three consecutive days. On a single day (day 2) the wheel was locked to prevent running. Wheel running correlated negatively with the frontal-parietal ratio of slow-wave activity (EEG power between 0.75 and 4.0 Hz) in the first 2 h after sleep onset (r = -0.60; P < 0.01). On day 2 frontal EEG power (2.25-8.0 Hz) in non-rapid eye movement sleep exceeded the level of the previous day, indicating that the diverse behaviors replacing wheel-running elicited more pronounced regional EEG differences. The frontal-parietal power ratio of the lower frequency bin (0.75-1.0 Hz) in the first 2 h of sleep after dark onset correlated positively with the duration of the preceding waking (r = 0.64; P < 0.001), whereas the power ratio in the remaining frequencies of the delta band (1.25-4.0 Hz) was unrelated to waking. The data suggest that in mice EEG power in the lower frequency, corresponding to the slow oscillations described in cats and humans, is related to local sleep homeostasis.
冬眠动物的慢波活动正在消失。
DOI：
--
发表时间：
1998
期刊：
Sleep research online [electronic resource] : SRO.
影响因子：
--
作者：
Larkin,JE;Heller,CH
通讯作者：
Heller,CH