Omega-3 fatty acids for a better mental state in working populations - Happy Nurse Project: A 52-week randomized controlled trial
Omega-3 fatty acids for a better mental state in working populations - Happy Nurse Project: A 52-week randomized controlled trial
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Omega-3 脂肪酸可改善工作人群的精神状态 - 快乐护士项目：一项为期 52 周的随机对照试验
DOI：
10.1016/j.jpsychires.2018.03.015
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发表时间：
2018
期刊：
影响因子：
4.8
通讯作者：
T. A.
中科院分区：
文献类型：
--
作者：
Watanabe;N. Matsuoka;Y. Kumachi;M. Hamazaki;K. Horikoshi;M. Furukawa;T. A.
欧米茄-3脂肪酸对保持更好的精神状态的有效性尚未在工作人群中进行检验。我们的目的是探索欧米茄-3脂肪酸对医院护士的有效性。在一项多中心随机试验中，80名初级护士被随机分配到omega-3脂肪酸(每天1200 mg二十碳五烯酸和600 mg二十二碳六烯酸)或相同的安慰剂药片中，为期13周。主要结果是医院焦虑和抑郁量表(HADS)的总分，由盲评者在第26周从研究登记开始确定。次要结果包括13周和52周的HADS总分；严重抑郁发作的发生率；抑郁、焦虑、失眠、倦怠和出勤的严重程度；效用评分；以及13周、26周和52周的不良事件。基线时HADS评分平均为7.2分。26周时，干预组HADS调整后平均分为6.32(95%标准差CI：5.13，7.52)，安慰剂组为6.81(5.57，8.05)。按时间交互作用分组的系数在0.58时无统计学意义(−为1.35，2.5；P = 为0.557)。尽管干预组在52周的HADS评分、52周的抑郁严重程度、13周的失眠严重程度和26周的绝对出勤率方面具有显著的优势，但在其他结果上没有明显的优势或劣势。关于精神状态和自我评估的工作效率，omega-3脂肪酸的附加值没有得到证实。
The efficacy of omega-3 fatty acids for maintaining a better mental state has not been examined among working populations. We aimed to explore the effectiveness of omega-3 fatty acids for hospital nurses. In a multi-center randomized trial, 80 junior nurses were randomly allocated to either omega-3 fatty acids (1200 mg/day of eicosapentaenoic acid and 600 mg/day of docosahexaenoic acid) or identical placebo pills for 13 weeks. The primary outcome was the total score of the Hospital Anxiety and Depression Scale (HADS), determined by a blinded rater at week 26 from the study enrolment. Secondary outcomes included the total score of the HADS at 13 and 52 weeks; incidence of a major depressive episode; severity of depression, anxiety, insomnia, burnout, and presenteeism; utility scores; and adverse events at 13, 26 and 52 weeks. The mean HADS score at baseline was 7.2. At 26 weeks, adjusted mean scores on the HADS were 6.32 (95% CIs of standard errors: 5.13, 7.52) in the intervention and 6.81 (5.57, 8.05) in the placebo groups, respectively. The coefficient of the group by time interaction was not statistically significant at 0.58 (−1.35, 2.50; P = 0.557). Although the intervention group showed significant superiority on the HADS score at 52 weeks, depression severity at 52 weeks, insomnia severity at 13 weeks, and absolute presenteeism at 26 weeks, no significant superiority or inferiority was observed on the other outcomes. The additive value of omega-3 fatty acids was not confirmed regarding mental state and self-evaluated work efficiency.