The value of red blood cell distribution width in endometrial cancer
The value of red blood cell distribution width in endometrial cancer
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DOI：
10.1515/cclm-2014-0699
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发表时间：
2015-04-01
影响因子：
6.8
通讯作者：
Yucel, Idris
中科院分区：
文献类型：
--
作者：
Kemal, Yasemin;Demirag, Guzin;Yucel, Idris
背景：红细胞分布宽度（RDW）是全血细胞计数的常规检测参数。在最近的研究中，RDW水平与心血管、肝脏和肾脏疾病以及实体瘤相关。本研究的目的是评估绝经后出血的良性和恶性原因的RDW水平的变化，并探讨RDW水平与子宫内膜癌（EC）patients.Methods的临床病理参数之间的关联：一项回顾性研究，共884名女性谁是入院治疗绝经后出血2009年5月至2013年12月。在应用入选和排除标准后，222例患者仍然存在。全血细胞计数数据来自记录的计算机化数据库。结果：EC组（n=113）的RDW水平显著高于良性组（14.78 +/- 2.02 vs. 13.88 +/- 1.05; p=0.000）。II级及以上EC患者的RDW水平高于I级患者（15.2 +/- 2.3 vs. 14.1 +/- 1.00; p=0.005）。相关分析还显示RDW与血红蛋白水平呈负相关RDW与红细胞平均体积（p = 0.000）、RDW与淋巴细胞计数（p=0.035）、RDW与血小板/淋巴细胞比值（p=0.030）呈正相关。RDW和EC患者的临床病理特征之间也存在显著相关性。
Background: Red cell distribution width (RDW) is a routinely examined parameter with the complete blood count. In recent studies, RDW levels have been associated with cardiovascular, liver and renal diseases and solid tumors. The aim of this study was to evaluate the alterations of RDW levels in benign and malignant causes of postmenopausal bleeding and to investigate the association of RDW levels with clinicopathological parameters of endometrial cancer (EC) patients.Methods: A retrospective study was made of a total of 884 females who were admitted to hospital for postmenopausal bleeding between May 2009 and December 2013. After inclusion and exclusion criteria were applied, 222 patients remained. Complete blood count data was obtained from the recorded computerized database. After pathological evaluation, the patients were divided into two groups, benign and malignant (EC).Results: The EC group (n=113) had significantly higher RDW levels compared to the benign group (14.78 +/- 2.02 vs. 13.88 +/- 1.05; p=0.000). Grade II and above EC patients had higher levels of RDW than Grade I patients (15.2 +/- 2.3 vs. 14.1 +/- 1.00; p=0.005). Correlation analyses also revealed a negative correlation between RDW and hemoglobin levels (p=0.000), RDW and mean corpuscular volume (p=0.000), RDW and lymphocyte count (p=0.035) but a positive correlation between RDW and platelet to lymphocyte ratio (p=0.030).Conclusions: The results of the current study revealed the potential predicitve role of RDW in patients with postmenopausal bleeding. Significant associations were also determined between RDW and clinicopathological characteristics in EC patients.