Themes reported by families as important when proceeding with pediatric hematopoietic stem cell transplantation.
Themes reported by families as important when proceeding with pediatric hematopoietic stem cell transplantation.
复制标题
家庭报告的主题在进行儿科造血干细胞移植时很重要。
DOI：
10.1002/pbc.25075
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发表时间：
2014
影响因子：
3.2
通讯作者：
Pentz,RebeccaD
中科院分区：
文献类型：
--
作者：
Pelletier,Wendy;Hinds,PamelaS;Alderfer,MelissaA;Fairclough,DianeL;Stegenga,Kristin;Pentz,RebeccaD
造血干细胞移植（HSCT）是儿科恶性和非恶性疾病的公认治疗方法。同意HSCT对家庭来说可能是一个挑战。本研究探讨了家庭成员报告的影响他们接受HSCT作为必要治疗干预的主题。在一项四中心研究中，在进行HSCT前对30个家庭中的107名儿童恶性肿瘤患者进行了HSCT治疗，对6个家庭中的25名儿童非恶性肿瘤患者进行了HSCT治疗。在二次分析中使用语义内容分析来确定相关主题。结果58名父母（和代父母）19名患者、16名供体兄弟姐妹和39名非供体兄弟姐妹、半兄弟姐妹和表兄妹参与了研究。确定了13个影响HSCT接受度的主题。最常见的报道是：“儿童医生的建议”，将HSCT视为“治愈的最佳机会”，以及“希望患者和家属过上更正常、更好质量的生活”。所有类别的家庭成员都报告了七个主题，尽管频率不同。两个主题（“HSCT是前期治疗计划的一部分”：“听说他人HSCT成功”）仅由恶性肿瘤组报道，一个主题（“担心疾病进展和失去HSCT机会窗口”）仅由非恶性肿瘤组报道。结论：家长、患者和其他家庭成员可以清楚地表达影响他们考虑移植的多个主题。了解这些主题可以指导家庭和医疗团队之间的讨论。中华儿科血癌杂志；2014;31(1):625 - 631。©2014 Wiley期刊公司
BackgroundHematopoietic stem cell transplantation (HSCT) is an accepted treatment for pediatric malignant and non‐malignant conditions. Agreeing to HSCT can be challenging for families. This study explored themes reported by family members as influencing their acceptance of HSCT as a necessary treatment intervention.ProcedureIn a four‐site study, 107 individuals within 30 families pursuing HSCT for a pediatric malignancy, and 25 individuals within 6 families pursuing HSCT for a pediatric non‐malignancy were interviewed pre‐HSCT. Semantic content analysis was used in this secondary analysis to identify relevant themes.ResultsFifty‐eight parents (and surrogates) 19 patients, 16 donor siblings, and 39 non‐donor siblings, half‐siblings and cousins, participated. Thirteen themes were identified as influencing the acceptance of HSCT. The most frequently reported were: “recommendation by the child's physician,” viewing HSCT as the “best chance for cure,” and “desiring a more normal and better quality of life for the patient and family.” Seven themes were reported by all categories of family members, though at different frequencies. Two themes (“HSCT being part of the upfront treatment plan”: “hearing of HSCT success in others”) were only reported by the malignancy group, and one theme (“worrying about disease progression and losing a window of HSCT opportunity”) was only reported by the non‐malignancy group.ConclusionParents, patients, and other family members can articulate multiple themes that influence their considerations of HSCT. Understanding these themes may guide discussions between families and healthcare teams. Pediatr Blood Cancer 2014;61:1625–1631. © 2014 Wiley Periodicals, Inc.