A highly diastereomerically enriched benzyllithium compound: The molecular structure and the stereochemical course of its transformations
A highly diastereomerically enriched benzyllithium compound: The molecular structure and the stereochemical course of its transformations
复制标题
高度非对映体富集的苄基锂化合物：分子结构及其转化的立体化学过程
DOI：
10.1021/om0201664
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发表时间：
2002
期刊：
影响因子：
2.8
通讯作者：
Daniel Schildbach
中科院分区：
文献类型：
--
作者：
C. Strohmann;Klaus Lehmen;K. Wild;Daniel Schildbach
The solid state structure of the lithiated [(benzylsilyl)methyl]amine Me2Si{[R]-[CHLiPh]}(CH2SMP) [(R,S)-2] {SMP = 1-[(S)-2-(methoxymethyl)pyrrolidinyl]} and the absolute configuration at the metalated carbon center of this alkyllithium compound, which is highly diastereomerically enriched in solution, were determined by single-crystal X-ray diffraction methods. The stereochemical course of an integral sequence of transformations, starting from unmetalated [(benzylsilyl)methyl]amine 1, was experimentally clarified. For the selective reaction of [(R,S)-2] with MeI, inversion of the configuration at the metalated carbon center was found.
