Contrast-enhanced ultrasound for molecular imaging of angiogenesis
Contrast-enhanced ultrasound for molecular imaging of angiogenesis
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DOI：
10.1007/s00259-010-1449-6
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发表时间：
2010-08-01
影响因子：
9.1
通讯作者：
Forsberg, F.
中科院分区：
文献类型：
--
作者：
Eisenbrey, J. R.;Forsberg, F.
使用对比增强超声的血管生成的分子成像允许功能性的、实时的、廉价的血管生成成像。添加稳定的微泡作为造影剂大大改善了超声信噪比/信号强度/图像质量（高达25 dB），并允许血管生成血管成像。在这篇文章中，最近的进展，在使用造影剂-本文综述了超声增强血管生成分子显像的研究进展，介绍了超声增强血管生成分子显像剂的应用及其显像参数与血管生成分子标志物之间的关系，综述针对血管生成标记物的超声造影剂的诊断和监测的最新发展进行了讨论。最后，一个简短的概述了新兴领域的化疗药物，可用于超声触发的药物输送，提供。
Molecular imaging of angiogenesis using contrast-enhanced ultrasound allows for functional, real-time, inexpensive imaging of angiogenesis. The addition of stabilized microbubbles as contrast agents greatly improves ultrasound signal to noise ratio/signal strength/image quality (up to 25 dB) and allows for imaging of angiogenic vasculature.In this article recent advances in the usage of contrast-enhanced ultrasound for molecular imaging of angiogenesis are reviewed.The usage of commercially available agents and correlations between their imaging parameters and molecular markers of angiogenesis are reviewed. Recent developments in ultrasound contrast agents targeted to angiogenic markers for both diagnosis and monitoring are discussed. Finally, a brief overview of the emerging field of chemotherapeutic-loaded agents, which can be used with ultrasound-triggered drug delivery, is provided.