Evoked K-complex generation: the impact of sleep spindles and age
Evoked K-complex generation: the impact of sleep spindles and age
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DOI：
10.1016/j.clinph.2003.10.014
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发表时间：
2004-02-01
影响因子：
4.7
通讯作者：
Colrain, IM
中科院分区：
文献类型：
--
作者：
Crowley, K;Trinder, J;Colrain, IM
目的：有人提出，纺锤体和自发 K 复合体反映了硬币的两面，纺锤体反映了抑制性微观状态，K 复合体反映了兴奋性或激发性微观状态 [Physiol Behav 1993;54(4):795]。该假设预测，刺激呈现时睡眠纺锤波的存在将降低该刺激引发 K 复合体的可能性。本研究试图在年轻和老年受试者中检验这一假设。方法：10 名神经健康且未服用药物的年轻人和 7 名老年人在睡眠实验室度过了一晚。参照 A1 + A2，从 6 个金板电极（Fz、FCz、Cz、CPz、Pz 和 O2）记录 EEG。在纺锤体 (SP +) 期间或没有纺锤体 (SP -) 的情况下，双耳呈现比测量的清醒检测阈值高 80 dB 的音调喀哒声 (1000 Hz)。这是通过查看中央脑电图通道来实现的，该通道被过滤为仅通过 12 至 14 Hz 之间的频率。根据是否产生 (KC +) 或 (KC -) K 复合物对试验进行进一步分类。使用年龄和纺锤体存在/不存在作为主要影响的双向方差分析来评估 KC + 试验的平均诱发电位的 K 复合体概率以及 N550 分量的振幅和潜伏期。结果：作为年龄的函数，K 复合体概率和 N550 振幅显着降低，N550 潜伏期显着增加。然而，没有变量显示纺锤体存在/不存在或年龄 X 纺锤体相互作用效应的显着影响。结论：无论是在 K 复合物被引发的可能性还是在其引发时的幅度 (N550) 方面，数据均未能支持睡眠纺锤体与 K 复合物产生拮抗的假设。 K 复合体生成不存在纺锤体效应，这反驳了它们是硬币的两面，并支持 K 复合体具有丘脑外或非特异性生成机制的概念。 (C) 2004 年国际临床神经生理学联合会。由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Objective: It has been proposed that spindles and spontaneous K-complexes reflect two sides of a coin, with the spindle reflecting an inhibitory microstate and the K-complex reflecting an excitatory or aroused microstate [Physiol Behav 1993;54(4):795]. This hypothesis predicts that the presence of a sleep spindle at the time of stimulus presentation would decrease the likelihood of a K-complex being elicited by that stimulus. The present study sought to test this hypothesis in young and elderly subjects.Methods: Ten young and 7 elderly adults who were neurologically healthy and free from medications spent one night in the sleep laboratory. EEG was recorded from 6 gold plate electrodes (Fz, FCz, Cz, CPz, Pz and O2) referenced to A1 + A2. Tone clicks (1000 Hz) at 80 dB above measured awake detection thresholds were presented binaurally either during a spindle (SP +) or in the absence of a spindle (SP -). This was achieved by viewing a central EEG channel filtered to pass only the frequencies between 12 and 14 Hz. Trials were further classified based on whether (KC +) or not (KC -) they produced a K-complex. K-Complex probability and the amplitude and latency of the N550 component of the averaged evoked potential for KC + trials were assessed using a two-way analysis of variance with main effects of age and spindle presence/absence.Results: There were significant reductions in K-complex probability and N550 amplitude and a significant increase in N550 latency, as a function of age. However, no variable displayed a significant effect of spindle presence/absence, or an age X spindle interaction effect.Conclusions: The data failed to support the hypothesis that sleep spindles are antagonistic to the production of K-complexes, both in terms of the likelihood of K-complexes being elicited or in their amplitude when elicited (N550). The absence of spindle effects on K-complex generation argues against them being two sides of a coin and supports the notion of K-complexes having an extra-thalamic or non-specific generation mechanism. (C) 2004 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.