The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond.
The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond.
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DOI：
10.1186/1471-2318-7-28
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发表时间：
2007-12-05
期刊：
影响因子：
4.1
通讯作者：
Starr JM
中科院分区：
文献类型：
--
作者：
Deary IJ;Gow AJ;Taylor MD;Corley J;Brett C;Wilson V;Campbell H;Whalley LJ;Visscher PM;Porteous DJ;Starr JM
认知老化是社会的重大负担，也是降低人们独立性和生活质量的主要影响因素。这是衰老最可怕的一面。与年龄相关的认知变化存在很大的个体差异。寻找认知老化的决定因素是研究的重点。许多研究的局限性是缺乏足够长的认知评估之间的时间来检查决定因素。在这里，目的是研究儿童和老年之间对认知衰老的影响。本研究为随访队列研究。参与者包括居住在苏格兰爱丁堡地区（洛锡安）的1947年苏格兰心理调查（SMS1947; N = 70,805）的幸存成员。SMS1947对所有1936年出生并于1947年6月在苏格兰学校上学的儿童进行了有效的一般智力测试。共有1091名参与者组成了1936年洛锡安出生队列。他们进行了：医疗面谈和检查；体能测试；广泛的认知测试（推理、记忆、信息处理速度和执行功能）；人格、生活质量等心理社会问卷；还有一份食物频率调查问卷。他们分别在11岁和70岁时接受了同样的智力测试（马里屋测试第12号）。他们为DNA提取和测试以及其他生物标志物分析提供了血液样本。在这里，我们描述了研究的背景和目的，招募程序和测试号码的细节，以及所有考试的细节。这个队列的主要优势是很少捕获的终身认知变化的表型。还有其他丰富的信息来研究这种终生认知变化中个体差异的决定因素。该方案报告在提醒其他研究人员注意队列中可用的数据方面很重要。
Cognitive ageing is a major burden for society and a major influence in lowering people's independence and quality of life. It is the most feared aspect of ageing. There are large individual differences in age-related cognitive changes. Seeking the determinants of cognitive ageing is a research priority. A limitation of many studies is the lack of a sufficiently long period between cognitive assessments to examine determinants. Here, the aim is to examine influences on cognitive ageing between childhood and old age. The study is designed as a follow-up cohort study. The participants comprise surviving members of the Scottish Mental Survey of 1947 (SMS1947; N = 70,805) who reside in the Edinburgh area (Lothian) of Scotland. The SMS1947 applied a valid test of general intelligence to all children born in 1936 and attending Scottish schools in June 1947. A total of 1091 participants make up the Lothian Birth Cohort 1936. They undertook: a medical interview and examination; physical fitness testing; extensive cognitive testing (reasoning, memory, speed of information processing, and executive function); personality, quality of life and other psycho-social questionnaires; and a food frequency questionnaire. They have taken the same mental ability test (the Moray House Test No. 12) at age 11 and age 70. They provided blood samples for DNA extraction and testing and other biomarker analyses. Here we describe the background and aims of the study, the recruitment procedures and details of numbers tested, and the details of all examinations. The principal strength of this cohort is the rarely captured phenotype of lifetime cognitive change. There is additional rich information to examine the determinants of individual differences in this lifetime cognitive change. This protocol report is important in alerting other researchers to the data available in the cohort.