CpG oligodeoxynucleotides as DNA adjuvants in vertebrates and their applications in immunotherapy
CpG oligodeoxynucleotides as DNA adjuvants in vertebrates and their applications in immunotherapy
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DOI：
10.1016/j.intimp.2006.06.001
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发表时间：
2006-10-01
影响因子：
5.6
通讯作者：
Chaung, Hso-Chi
中科院分区：
文献类型：
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作者：
Chaung, Hso-Chi
细菌和病毒DNA的基因组含有比脊椎动物高得多的频率的未甲基化的CpG二核苷酸。这种基因组结构的差异使得脊椎动物的先天免疫系统能够将细菌或病毒DNA与自身DNA区分开来，从而在遇到细菌或病毒DNA时感知到“危险信号”。多种证据表明，CpG基序，包括细菌DNA和CpG ODN（含有未甲基化CpG的合成寡脱氧核苷酸），能够在脊椎动物中引起一系列免疫刺激作用，并具有作为治疗剂和佐剂的巨大潜力。具有不同序列的CpG基序已显示诱导各种类型或水平的免疫刺激应答，而CpG基序的免疫刺激作用是物种特异性的。在分子水平上更好地理解CpG识别对于鉴定具有所需免疫刺激反应的那些基序是至关重要的。希望这将允许优化和应用CpG基序作为治疗剂和佐剂，用于各种物种中的许多疾病。(c)2006 Elsevier B.V.保留所有权利。
The genomes of bacterial and viral DNA contain a much higher frequency of unmethylated CpG dinucleotides than those of vertebrates. This difference in genome structure allows the innate immune system of vertebrates to distinguish bacterial or viral DNA from self-DNA, and consequently to perceive a 'danger signal' when bacterial or viral DNA is encountered. Multiple sources of evidence suggest that CpG motifs, including bacterial DNA and CpG ODNs (synthetic oligodeoxynucleotides containing unmethylated CpG), are capable of evoking a range of immunostimulatory effects in vertebrates and have a tremendous potential to be used as therapeutic agents and adjuvants. CpG motifs with different sequences have been shown to induce various types or levels of immunostimulatory responses whereas the immunostimulatory effects of CpG motifs are species-specific. A better understanding of CpG recognition at the molecular level is fundamental to the identification of those motifs that have desired immunostimulatory responses. It is hoped that this would allow the optimization and application of CpG motifs as therapeutic agents and adjuvants, for numerous diseases in various species. (c) 2006 Elsevier B.V. All rights reserved.