Properties and molecular mechanisms underlying geniposide-mediated therapeutic effects in chronic inflammatory diseases
Properties and molecular mechanisms underlying geniposide-mediated therapeutic effects in chronic inflammatory diseases
复制标题
京尼平苷介导的慢性炎症疾病治疗作用的特性和分子机制
DOI：
10.1016/j.jep.2021.113958
复制
发表时间：
2021-03-03
影响因子：
5.4
通讯作者：
Wang Mengdie
中科院分区：
文献类型：
--
作者：
Deng Ran;Wu Hong;Wang Mengdie
民族药理学相关性：京尼平苷（GE）普遍存在于近40种植物中，其中以栀子含量最高，在民族药理学上已被用于治疗慢性炎症性疾病。栀子作为中药，在消肿镇静、保肝胆汁、降血压、止血等方面有着悠久的使用历史。常用于治疗糖尿病、高血压、黄疸型肝炎、扭伤挫伤等。 GE作为从栀子中提取的环烯醚萜苷类化合物，具有抗炎、抗血管生成、抗氧化等多种药理作用。综述目的：本文对GE的来源、传统用途、药代动力学、毒性及对慢性炎症性疾病的治疗作用进行综述，并探讨其潜在的调控机制和临床应用。在治疗慢性炎症性疾病方面具有很强的活性。大量体内外实验证实GE对多种慢性炎症性疾病具有一定的治疗价值。其作用机制主要基于其抗炎、抗氧化、神经保护特性以及细胞凋亡的调节。 GE通过调节细胞增殖和凋亡、实现促炎/抗炎因子的动态平衡、改善氧化应激状态、恢复异常表达的炎症相关通路等发挥治疗慢性炎症性疾病的作用。结论：GE具有广泛的药理作用，是一种很有前景的治疗慢性炎症性疾病的药物。
Ethnopharmacological relevance: Geniposide (GE) is ubiquitous in nearly 40 species of plants, among which Gardenia jasminoides J. Ellis has the highest content, and has been used ethnopharmacologically to treat chronic inflammatory diseases. As a traditional Chinese medicine, Gardenia jasminoides J. Ellis has a long history of usage in detumescence and sedation, liver protection and cholestasis, hypotension and hemostasis. It is commonly used in the treatment of diabetes, hypertension, jaundice hepatitis, sprain and contusion. As a type of iridoid glycosides extracted from Gardenia jasminoides J. Ellis, GE has many pharmacological effects, such as antiinflammatory, anti-angiogenesic, anti-oxidative, etc.Aim of the review: In this article, we reviewed the sources, traditional usage, pharmacokinetics, toxicity and therapeutic effect of GE on chronic inflammatory diseases, and discussed its potential regulatory mechanisms and clinical application.Results: GE is a common iridoid glycoside in medicinal plants, which has strong activity in the treatment of chronic inflammatory diseases. A large number of in vivo and in vitro experiments confirmed that GE has certain therapeutic value for a variety of chronic inflammation disease. Its mechanism of function is mainly based on its anti-inflammatory, anti-oxidant, neuroprotective properties, as well as regulation of apoptotsis. GE plays a role in the treatment of chronic inflammatory diseases by regulating cell proliferation and apoptosis, realizing the dynamic balance of pro/anti-inflammatory factors, improving the state of oxidative stress, and restoring abnormally expressed inflammation-related pathways.Conclusion: According to its extensive pharmacological effects, GE is a promising drug for the treatment of chronic inflammatory diseases.