Fluorine-18 fluorodeoxyglucose positron emission tomography predicts tumor differentiation, P-glycoprotein expression, and outcome after resection in hepatocellular carcinoma
Fluorine-18 fluorodeoxyglucose positron emission tomography predicts tumor differentiation, P-glycoprotein expression, and outcome after resection in hepatocellular carcinoma
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DOI：
10.1158/1078-0432.ccr-06-1357
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发表时间：
2007-01-15
影响因子：
11.5
通讯作者：
Uemoto, Shinji
中科院分区：
文献类型：
--
作者：
Seo, Satoru;Hatano, Etsuro;Uemoto, Shinji
目的：探讨氟 18 氟脱氧葡萄糖正电子发射断层扫描 (FDG-PET) 对预测肝细胞癌 (HCC) 患者肿瘤分化、P-糖蛋白 (P-gp) 表达和预后的诊断价值。 实验设计：前瞻性地将 70 名接受根治性切除的 HCC 患者纳入该研究。术前2周进行FDG-PET检查，根据FDG摄取量计算标准化摄取值(SUV)和肿瘤与非肿瘤SUV比值(TNR)。分别用H&E和免疫组化染色检测肿瘤分化和P-gp表达。结果：低分化HCC中SUV和TNR显着高于高分化HCC（P = 0.001和0.002）和中分化HCC（P < 0.0001和P < 0.0001）。高分化 HCC 中 P-gp 阳性面积百分比显着高于低分化 (P < 0.0001) 和中分化 HCC (P = 0.0001)。 SUV 和 P-gp 表达之间（r = -0.44；P < 0.0001）以及 TNR 和 P-gp 表达之间（r = -0.47；P = 0.01）之间发现负相关。 43 例（61.4%）患者术后复发。高 TNR 条件下的总生存率和无病生存率（
Purpose: To investigate the diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) for prediction of tumor differentiation, P-glycoprotein (P-gp) expression, and outcome in hepatocellular carcinoma (HCC) patients.Experimental Design: Seventy HCC patients who underwent curative resection were prospectively enrolled in the study. FDG-PET was done 2 weeks preoperatively, and the standardized uptake value (SUV) and the tumor to nontumor SUV ratio (TNR) were calculated from FDG uptake. Tumor differentiation and P-gp expression were examined with H&E and immunohistochemical staining, respectively.Results: SUV and TNR were significantly higher in poorly differentiated HCCs than in well-differentiated (P = 0.001 and 0.002) and moderately differentiated HCCs (P < 0.0001 and P < 0.0001). The percentage P-gp-positive area was significantly higher in well-differentiated HCCs than in poorly differentiated (P < 0.0001) and moderately differentiated HCCs (P = 0.0001). Inverse correlations were found between SUV and P-gp expression (r = -0.44; P < 0.0001) and between TNR and P-gp expression (r = -0.47; P = 0.01). Forty-three (61.4%) patients had postoperative recurrence. The overall and disease-free survival rates in the high TNR (