Brain tumor perfusion: Comparison of dynamic contrast enhanced magnetic resonance imaging using T1, T2, and T2* contrast, pulsed arterial spin labeling, and H215O positron emission tomography
Brain tumor perfusion: Comparison of dynamic contrast enhanced magnetic resonance imaging using T1, T2, and T2* contrast, pulsed arterial spin labeling, and H215O positron emission tomography
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DOI：
10.1016/j.ejrad.2008.02.012
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发表时间：
2009-06-01
影响因子：
3.3
通讯作者：
Amthauer, Holger
中科院分区：
文献类型：
--
作者：
Luedemann, Lutz;Warmuth, Carsten;Amthauer, Holger
目的：不同的技术测量灌注是临床上可用的，但这些通常是适用于健康的脑tissue.Material和方法：五种不同的技术在这里使用了12例脑肿瘤的肿瘤血管化的灌注信号的影响进行调查：三种定性动态对比增强/磁共振成像（DCE-MRI/DSC-MRI）技术利用T（1）、T（2）、T（2）* 对比度和两种定量技术，脉冲动脉自旋标记（PASL）和H（2）（15）O正电子发射断层扫描（H（2）（15）O-PET）。在第一近似中，在关于正常脑组织和肿瘤两者的灌注信号的所有五种成像模式之间发现线性相关性。肿瘤灌注的估计值在不同技术之间存在显著差异（1=任意单位的方法平均值）：PASL：0.83，H（2）（15）O-PET- 0.62，T（1）-DCE：1.73，T（2）-DCE：0.69，T（2）*-DSC：0.89。结论：不同技术测定的肿瘤灌注值不具有可比性。T2*-DSC（此处应用血管外空间的造影剂预饱和）和PASL最可靠地描绘了中值灌注。(C)2008年由Elsevier爱尔兰有限公司出版。
Objectives: Different techniques for measuring of perfusion are clinically available, but these are usually applied to healthy brain tissue.Material and methods: Five different techniques were used here in 12 patients with brain tumors to investigate the impact of tumor vascularization on the perfusion signal: three qualitative dynamic contrast-enhanced/susceptibility-contrast magnetic resonance imaging (DCE-MRI/DSC-MRI) techniques exploiting T(1), T(2), T(2)* contrast, and two quantitative techniques, pulsed arterial spin labeling (PASL) and H(2)(15)O positron emission tomography (H(2)(15)O-PET).Results: In a first approximation, a linear correlation was found between all five imaging modalities regarding the perfusion signal of both, normal brain tissue and tumor. The estimated values for tumor perfusion differed significantly between the techniques (1=methodical mean in arbitrary units): PASL: 0.83, H(2)(15)O-PET- 0.62, T(1)-DCE: 1.73, T(2)-DCE: 0.69, T(2)*-DSC: 0.89.Conclusions: The tumor perfusion values, determined with different techniques are not comparable. The T2*-DSC, here applied with contrast agent presaturation of extravascular space, and PASL depict median perfusion most reliably. (C) 2008 Published by Elsevier Ireland Ltd.