Genetic basis of tobacco smoking:: strong association of a specific major histocompatibility complex haplotype on chromosome 6 with smoking behavior
Genetic basis of tobacco smoking:: strong association of a specific major histocompatibility complex haplotype on chromosome 6 with smoking behavior
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DOI：
10.1093/intimm/dxh152
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发表时间：
2004-10-01
影响因子：
4.4
通讯作者：
Yu, CY
中科院分区：
文献类型：
--
作者：
Füst, G;Arason, GJ;Yu, CY
吸烟成瘾的遗传基础--特别是对嗅觉刺激的感知可能是强化吸烟成瘾的重要因素--在很大程度上是未知的。嗅觉受体基因簇位于6号染色体MHC区域附近。对101例健康受试者和232例有明确吸烟习惯的匈牙利冠心病患者的MHC-III类基因(RCCX模块，TNFA启动子多态性)进行了检测。观察到曾经吸烟(过去+现在吸烟者)和特定的MHC单倍型之间的高度显著的关联(优势比=2.144.13；P值=0.012
The genetic basis for addiction to tobacco smoking-particularly that of the perception of olfactory stimuli that may be important in reinforcing smoking addiction-is largely unknown. A cluster of genes for olfactory receptors is in close proximity to the MHC region on chromosome 6. Polymorphisms of MHC class III genes (RCCX modules, TNFA promoter polymorphisms) were determined in 101 healthy subjects and 232 coronary artery disease (CAD) patients from Hungary with defined tobacco smoking habits. A highly significant association between ever smoking (past + current smokers) and a specific MHC haplotype was observed (odds ratios = 2.14-4.13; P-values = 0.012 to