Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age.
Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age.
复制标题
无论年龄如何，EB 病毒阳性弥漫性大 B 细胞淋巴瘤都预示着不良预后。
DOI：
10.1038/srep12168
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发表时间：
2015-07-23
影响因子：
4.6
通讯作者：
Li JY
中科院分区：
文献类型：
--
作者：
Lu TX;Liang JH;Miao Y;Fan L;Wang L;Qu XY;Cao L;Gong QX;Wang Z;Zhang ZH;Xu W;Li JY
EB病毒(EBV)阳性的老年人弥漫性大B细胞淋巴瘤(DLBCL)是指年龄在50岁以上的患者。然而，最近的研究表明，免疫状况良好的年轻患者也可能受到影响。在这项研究中，我们调查了不同年龄组EBV阳性DLBCL患者的临床特征和预后，采用不同的EBER分界值。EBER分界值为20%和50%时，EBV阳性DLBCL的患病率分别为14.0%(35/250)和10.4%(26/250)。EBV DLBCL患者的EBER分界值与年龄无关，都有许多预后不良的特征。EBV阳性患者，无论是老年组还是青年组，总体存活率和无进展存活率均显著低于EBV阴性患者。此外，EBV阳性DLBCL的不同年龄组之间的预后没有显著差异。综上所述，EBV阳性的DLBCL患者，无论年龄大小，都有相似的不良预后特征，其预后也比阴性患者差。我们建议今后修改老年人EBV阳性DLBCL的年龄标准，并可能修改其名称本身。
Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) of the elderly is defined as patients older than 50 years alone. However, recent studies showed young patients with sound immune status could also be affected. In this study, we investigated the clinical features and outcomes of patients with EBV positive DLBCL in the different age groups using different EBER cut-off values. The prevalence of EBV positive DLBCL was 14.0% (35/250) and 10.4% (26/250) for EBER cut-off of 20% and 50%, respectively. With both EBER cut-off values, patients with EBV DLBCL shared many unfavorable prognostic characteristics, regardless of age. EBV positive patients, both in the elderly and young groups, showed significantly worse overall survival and progression-free survival than negative cases. Moreover, no significant differences of outcomes were identified between different age groups with EBV positive DLBCL. In conclusion, EBV positive DLBCL patients, regardless of age, shared similar poor prognostic features and showed worse outcome than negative cases. We suggest that the age criterion of EBV positive DLBCL of the elderly, and possibly the name itself, be modified in future.