Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy
复制标题
DOI：
10.1002/dad2.12053
复制
发表时间：
2020-01-01
影响因子：
5.3
通讯作者：
Verma, Ajay
中科院分区：
文献类型：
--
作者：
Carare, Roxana O.;Aldea, Roxana;Verma, Ajay
大脑中动脉的两个关键功能是(1)公认的通过血管管腔的血液供应和(2)动脉壁作为从大脑和视网膜清除间质液体(ISF)和可溶性代谢物(如淀粉样β蛋白(Aβ))的新出现的作用。由于大脑和视网膜没有常规的淋巴管，向周围淋巴结的液体排出是通过毛细血管和动脉壁中的基底膜运输来实现的，这些基膜形成了动脉壁周围引流系统(IPad)。随着动脉的老化，iPad往往会失效，但这种失效背后的机制尚不清楚。在一些人中，这反映在阿尔茨海默病(AD)患者大脑中Aβ斑块的积累和动脉壁中Aβ蛋白的沉积，称为脑淀粉样血管病(CAA)。了解iPad的动态变化及其随年龄增长而失效的原因，对于建立对疾病早期阶段的诊断测试，以及设计在预防和治疗AD和CAA中促进Aβ清除的疗法至关重要。这篇社论旨在介绍导致在阿尔茨海默氏症协会推进阿尔茨海默氏症研究和治疗国际协会血管专业兴趣领域内建立间质液体清除(ISF)和脑脊液(CLIC)小组的基本原理。
Two of the key functions of arteries in the brain are (1) the well-recognized supply of blood via the vascular lumen and (2) the emerging role for the arterial walls as routes for the elimination of interstitial fluid (ISF) and soluble metabolites, such as amyloid beta (A beta), from the brain and retina. As the brain and retina possess no conventional lymphatic vessels, fluid drainage toward peripheral lymph nodes is mediated via transport along basement membranes in the walls of capillaries and arteries that form the intramural peri-arterial drainage (IPAD) system. IPAD tends to fail as arteries age but the mechanisms underlying the failure are unclear. In some people this is reflected in the accumulation of A beta plaques in the brain in Alzheimer's disease (AD) and deposition of A beta within artery walls as cerebral amyloid angiopathy (CAA). Knowledge of the dynamics of IPAD and why it fails with age is essential for establishing diagnostic tests for the early stages of the disease and for devising therapies that promote the clearance of A beta in the prevention and treatment of AD and CAA. This editorial is intended to introduce the rationale that has led to the establishment of the Clearance of Interstitial Fluid (ISF) and CSF (CLIC) group, within the Vascular Professional Interest Area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment.