Ginsenoside, Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats
Ginsenoside, Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats
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DOI：
10.1016/j.ejphar.2006.08.056
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发表时间：
2006-11-21
影响因子：
5
通讯作者：
Yue, Kevin K. M.
中科院分区：
文献类型：
--
作者：
Cho, William C. S.;Chung, Wai-Shing;Yue, Kevin K. M.
糖尿病的特点是高血糖和影响眼睛、肾脏、神经和血管的并发症。我们之前已经证明了链脲佐菌素诱导的糖尿病大鼠氧化应激的发生，在组织水平的谷胱甘肽耗尽之前。在本研究中，给糖尿病大鼠服用人参皂苷Re后，血糖、总胆固醇和甘油三酯水平明显降低。另一方面，氧化应激与糖尿病及其并发症的发病机制有关。研究发现，人参皂苷Re治疗使眼睛和肾脏中的谷胱甘肽和丙二醛水平恢复到对照大鼠的水平。这是首次报道人参皂苷Re对糖尿病具有显著的抗氧化作用，并能防止一些血管组织氧化应激的发生。结果表明，人参皂苷Re能够降低糖尿病大鼠的血糖和血脂水平，并对眼睛和肾脏氧化应激的发生具有保护作用。我们的数据也提供了证据，人参皂苷Re可以作为一种有效的降糖剂，特别是在预防糖尿病微血管病变。(c) 2006 Elsevier B.V.版权所有
Diabetes mellitus is characterized by hyperglycemia and complications affecting the eye, kidney, nerve and blood vessel. We have previously demonstrated the occurrence of oxidative stress of streptozotocin-induced diabetic rats, preceded by a depletion in the tissue level of glutathione. In this study, when diabetic rats were treated with ginsenoside Re of Panax ginseng C.A. Meyer, there was a significant reduction in blood glucose, total cholesterol and triglyceride levels. On the other hand, oxidative stress has been implicated in the pathogenesis of diabetes and its complications. It was found that treatment by ginsenoside Re restored the levels of both glutathione and malondialdehyde in the eye and kidney to those found in the control rats. This is the first report demonstrating ginsenoside Re has significant antioxidant efficacy in diabetes, and prevents the onset of oxidative stress in some vascular tissues. Our results demonstrated that ginsenoside Re could lower blood glucose and lipid levels, and exerts protective actions against the occurrence of oxidative stress in the eye-and kidney of diabetic rats. Our data also provide evidence that ginsenoside Re could be used as an effective antidiabetic agent particularly in the prevention of diabetic microvasculopathy. (c) 2006 Elsevier B.V. All rights reserved.