The DRE sequence TATCGATA, a putative promoter-activating element for Drosophila melanogaster cell-proliferation-related genes
The DRE sequence TATCGATA, a putative promoter-activating element for Drosophila melanogaster cell-proliferation-related genes
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DOI：
10.1016/0378-1119(95)00586-2
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发表时间：
1995-12-12
期刊：
影响因子：
3.5
通讯作者：
Yamaguchi, M
中科院分区：
文献类型：
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作者：
Matsukage, A;Hirose, F;Yamaguchi, M
我们已经证实，DNA复制相关元件（DRE）由一个8 bp的回文序列，TATCGATA，而不是相邻的序列，负责激活启动子的果蝇（Dm）PCNA（增殖细胞核抗原）和DNA聚合酶α编码基因在培养细胞和转基因果蝇系统。目前为止，我们在Dm基因数据库中发现了153个DRE拷贝。其中73个集中在61个基因转录起始点上游600 bp的区域内。有趣的是，这些基因中的许多基因参与DNA复制、转录、翻译、信号转导、细胞周期或其他假定的调控功能，并且可能与细胞增殖有关。DRE似乎是调节细胞增殖相关基因的共同元件，尽管它们的表达模式可能不同，这取决于DRE以外的调节元件的组合。
We have confirmed that the DNA replication-related element (DRE) consisting of an 8-bp palindrome, TATCGATA, and not neighboring sequences, are responsible for activating promoters of the Drosophila melanogaster (Dm) PCNA (proliferating cell nuclear antigen)- and DNA polymerase alpha-encoding genes in both cultured cell and transgenic fly systems. We have so far found 153 copies of DRE in the Dm gene database. 73 of them are concentrated within the 600-bp upstream regions from the transcription start points of 61 genes. Interestingly, many of these genes are involved in either DNA replication, transcription, translation, signal transduction, cell cycle or other putative regulatory functions, and are possibly related to cell proliferation. It seems likely that DRE is an element common to the regulation of cell-proliferation-related genes, although their expression patterns may be different depending on which of regulatory elements other than the DRE are combined.