TEN(A), A DROSOPHILA GENE-RELATED TO TENASCIN, SHOWS SELECTIVE TRANSCRIPT LOCALIZATION
TEN(A), A DROSOPHILA GENE-RELATED TO TENASCIN, SHOWS SELECTIVE TRANSCRIPT LOCALIZATION
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DOI：
10.1016/0925-4773(93)90074-8
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发表时间：
1993-03-01
影响因子：
2.6
通讯作者：
CHIQUETEHRISMANN, R
中科院分区：
文献类型：
--
作者：
BAUMGARTNER, S;CHIQUETEHRISMANN, R
我们报告了果蝇基因 10(a*) 的鉴定和分子特征，该基因位于 X 染色体上的 11A6-9。推导的782个氨基酸的蛋白质含有8个以前在果蝇中未描述过的肌腱蛋白型EGF样重复序列，但缺乏纤连蛋白III型重复序列和脊椎动物肌腱蛋白分子中存在的纤维蛋白原同源性。 Ten(a) 编码一个大转录本，该转录本具有极长的 5' 和 3' 非翻译区。十（a）转录物显示细胞内特定的核周定位，并且主要在胚胎发生期间的中枢神经系统、大脑和肌肉附着位点附近表达。在蛹阶段，眼睛中检测到十（a）。这些表达模式让人想起脊椎动物腱蛋白的表达模式。在果蝇的其他基因座和各种其他生物体中也检测到生腱蛋白型 EGF 样序列，表明存在与生腱蛋白相关的基因家族。
We report the identification and molecular characterization of ten(a*), a Drosophila gene located at 11A6-9 on the X-chromosome. The deduced protein of 782 amino acids contains eight tenascin-type EGF-like repeats not described in Drosophila before, but lacks the fibronectin type III repeats and the fibrinogen homology present in the vertebrate tenascin molecules. Ten(a) codes for a large transcript which exhibits extremely long 5' and 3' untranslated regions. Ten(a) transcripts show a specific perinuclear localization within cells and are mainly expressed in the central nervous system, in the brain and near muscle attachment sites during embryogenesis. During pupal stages, ten(a) is detected in the eye. These expression patterns are reminiscent of those of vertebrate tenascin. Tenascin-type EGF-like sequences are also detected in other loci of Drosophila and in various other organisms, indicating the existence of a family of genes related to tenascin.