Genetic basis for adverse events after smallpox vaccination
Genetic basis for adverse events after smallpox vaccination
复制标题
DOI：
10.1086/588670
复制
发表时间：
2008-07-01
影响因子：
6.4
通讯作者：
Crowe, James E., Jr.
中科院分区：
文献类型：
--
作者：
Reif, David M.;McKinney, Brett A.;Crowe, James E., Jr.
识别与不良事件发生相关的遗传因素可能允许在接种牛痘病毒之前进行筛查。在健康的未接种过牛痘病毒的成年志愿者中进行了两项独立的天花疫苗（Aventis Pasteur）临床试验。志愿者反复评估与接受疫苗相关的局部和全身不良事件（AE），并对1442个单核苷酸多态性（SNP）进行基因分型。在第一项研究中，26个基因的36个SNP与全身性AE相关（P
Identifying genetic factors associated with the development of adverse events might allow screening before vaccinia virus administration. Two independent clinical trials of the smallpox vaccine (Aventis Pasteur) were conducted in healthy, vaccinia virus-naive adult volunteers. Volunteers were assessed repeatedly for local and systemic adverse events (AEs) associated with the receipt of vaccine and underwent genotyping for 1442 single-nucleotide polymorphisms (SNPs). In the first study, 36 SNPs in 26 genes were associated with systemic AEs (P