Chiral amino alcohol-mediated asymmetric conjugate addition of arylalkynes to nitroolefins.
Chiral amino alcohol-mediated asymmetric conjugate addition of arylalkynes to nitroolefins.
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DOI：
10.1021/ol050643p
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发表时间：
2005-05
期刊：
影响因子：
5.2
通讯作者：
M. Yamashita;Ken‐ichi Yamada;K. Tomioka
中科院分区：
文献类型：
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作者：
M. Yamashita;Ken‐ichi Yamada;K. Tomioka
[反应：以二甲基锌（或二乙基锌）和（1 R，2 R）-2-（二甲氨基）-1，2-二苯基乙醇为催化剂，在甲苯中进行了硝基烯烃与芳基炔的不对称反应，得到了对映体过量高达99%的共轭炔基化产物。0.03当量galvinoxyl的存在提高了反应产率。
[reaction: see text] The asymmetric reaction of nitroolefins with arylalkynes was mediated by dimethylzinc (or diethylzinc) and (1R,2R)-2-(dimethylamino)-1,2-diphenylethanol in toluene to provide the corresponding conjugate alkynylation products with high enantiomeric excess of up to 99% in good yields. The presence of 0.03 equiv of galvinoxyl improved the reaction yield.