Pericardial Fat Is Independently Associated With Human Atrial Fibrillation
Pericardial Fat Is Independently Associated With Human Atrial Fibrillation
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DOI：
10.1016/j.jacc.2010.03.071
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发表时间：
2010-08-31
影响因子：
24
通讯作者：
Akar, Joseph G.
中科院分区：
文献类型：
--
作者：
Al Chekakie, M. Obadah;Welles, Christine C.;Akar, Joseph G.
目的本研究的目的是探讨心房颤动（AF）与心包脂肪的关系。炎症和肥胖与AF有关，但AF和心包脂肪之间的关系尚不清楚。76例窦性心律患者，126例阵发性AF患者，结果与窦性心律患者相比，房颤患者的心包脂肪明显增多（101.6 +/- 44.1 ml对比76.1 +/- 36.3 ml，p < 0.001）。阵发性房颤组的心包脂肪体积显著大于窦性心律组（93.9 +/- 39.1 ml vs. 76.1 +/- 36.3 ml，p = 0.02）。持续性AF患者的心包脂肪体积显著大于阵发性AF患者（115.4 +/- 49.3 ml vs. 93.9 +/- 39.1 ml，p = 0.001）。心包脂肪体积与阵发性房颤相关（比值比：1.11; 95%置信区间：1.01至1.23，p = 0.04）和持续性AF（比值比：1.18，95%置信区间：1.05至1.33，p = 0.004），并且这种关联完全独立于年龄、高血压、性别、左心房扩大、心脏瓣膜病、左心室射血分数、糖尿病和体重指数。结论心包脂肪体积与阵发性和持续性房颤高度相关，与包括左心房扩大在内的传统危险因素无关。心包脂肪是否在房颤的发病机制中起作用需要进一步研究。（J Am科尔心脏病学杂志2010;56：784-8）（C）美国心脏病学会基金会2010年
ObjectivesThe purpose of this study was to investigate the association between atrial fibrillation (AF) and pericardial fat.BackgroundPericardial fat is visceral adipose tissue that possesses inflammatory properties. Inflammation and obesity are associated with AF, but the relationship between AF and pericardial fat is unknown.MethodsPericardial fat volume was measured using computed tomography in 273 patients: 76 patients in sinus rhythm, 126 patients with paroxysmal AF, and 71 patients with persistent AF.ResultsPatients with AF had significantly more pericardial fat compared with patients in sinus rhythm (101.6 +/- 44.1 ml vs. 76.1 +/- 36.3 ml, p < 0.001). Pericardial fat volume was significantly larger in paroxysmal AF compared with the sinus rhythm group (93.9 +/- 39.1 ml vs. 76.1 +/- 36.3 ml, p = 0.02). Persistent AF patients had a significantly larger pericardial fat volume compared with paroxysmal AF (115.4 +/- 49.3 ml vs. 93.9 +/- 39.1 ml, p = 0.001). Pericardial fat volume was associated with paroxysmal AF (odds ratio: 1.11; 95% confidence interval: 1.01 to 1.23, p = 0.04) and persistent AF (odds ratio: 1.18, 95% confidence interval: 1.05 to 1.33, p = 0.004), and this association was completely independent of age, hypertension, sex, left atrial enlargement, valvular heart disease, left ventricular ejection fraction, diabetes mellitus, and body mass index.ConclusionsPericardial fat volume is highly associated with paroxysmal and persistent AF independent of traditional risk factors including left atrial enlargement. Whether pericardial fat plays a role in the pathogenesis of AF requires future investigation. (J Am Coll Cardiol 2010;56:784-8) (C) 2010 by the American College of Cardiology Foundation