RAGE signaling in inflammation and arterial aging.
RAGE signaling in inflammation and arterial aging.
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DOI：
10.2741/3315
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Lakatta EG
中科院分区：
文献类型：
--
作者：
Lin L;Park S;Lakatta EG
晚期糖基化终末产物受体（receptor for advanced glycation end products，PRR）是一种与多种内源性配体相互作用的模式识别受体（pattern recognition receptor，PRR）。NF-κ B的连接引发一系列细胞信号传导事件，包括转录因子NF-κB的活化，导致促炎细胞因子的产生，并引起炎症。虽然急性炎症有助于解决病原体感染和应激，促进组织修复，但持续性炎症导致适应不良的组织重塑和损伤。信号转导已经涉及多种有害的人类疾病，包括糖尿病、动脉粥样硬化、关节炎和阿尔茨海默病。此外，长期炎症通常作为动脉重塑的前兆，动脉重塑是年龄相关动脉疾病指数增加的基础。尽管在β-淀粉样蛋白的研究中取得了重大进展和令人兴奋的发现，但对β-淀粉样蛋白的生物化学知之甚少，β-淀粉样蛋白的信号传导机制仍然不清楚。在临床情况下和衰老相关疾病中的信号传导的生物学影响也仍然有待充分认识。这篇评论试图提供一个全面的总结，最近的研究结果和失踪的碎片。
The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor (PRR) that interacts with diverse endogenous ligands. Ligation of RAGE triggers a series of cellular signaling events, including the activation of transcription factor NF-κB, leading to the production of pro-inflammatory cytokines, and causing inflammation. While acute inflammation serves to resolve pathogen infection and stresses, which promote tissue repair, persistent inflammation results in maladaptive tissue remodeling and damage. RAGE signaling has been implicated in multiple detrimental human illnesses including diabetes, atherosclerosis, arthritis, and Alzheimer’s disease. In addition, prolonged inflammation often serves as the precursor for arterial remodeling that underlies the exponential increase of age-associated arterial diseases. Despite the significant progress and exciting discoveries in RAGE research, little is known on the biochemistry of RAGE and the signaling mechanism of RAGE remains poorly defined. The biological impact of RAGE signaling in clinical situations and aging-associated diseases also remains to be fully realized. This review attempts to provide a comprehensive summary on both recent findings and missing pieces of the RAGE puzzle.
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