TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death.
TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death.
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DOI：
10.1038/ncomms3852
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发表时间：
2013
影响因子：
16.6
通讯作者：
Li, Hongliang
中科院分区：
文献类型：
--
作者：
Lu, Yan-Yun;Li, Zuo-Zhi;Jiang, Ding-Sheng;Wang, Lang;Zhang, Yan;Chen, Ke;Zhang, Xiao-Fei;Liu, Yi;Fan, Guo-Chang;Chen, Yingjie;Yang, Qinglin;Zhou, Yan;Zhang, Xiao-Dong;Liu, De-Pei;Li, Hongliang
Stroke is a leading global cause of mortality and disability. Less than 5% of patients are able to receive tissue plasminogen activator thrombolysis within the necessary timeframe. Focusing on the process of neuronal apoptosis in the penumbra, which lasts from hours to days after ischaemia, appears to be promising. Here we report that tumour necrosis factor receptor-associated factor 1 (TRAF1) expression is markedly induced in wild-type mice 6 h after stroke onset. Using genetic approaches, we demonstrate that increased neuronal TRAF1 leads to elevated neuronal death and enlarged ischaemic lesions, whereas TRAF1 deficiency is neuroprotective. In addition, TRAF1-mediated neuroapoptosis correlates with the activation of the JNK pro-death pathway and inhibition of the Akt cell survival pathway. Finally, TRAF1 is found to exert pro-apoptotic effects via direct interaction with ASK1. Thus, ASK1 positively and negatively regulates the JNK and Akt signalling pathways, respectively. Targeting the TRAF1/ASK1 pathway may provide feasible therapies for stroke long after onset. TRAF1 is an intracellular signalling molecule that has diverse biological functions. In this study, the authors show that TRAF1 is expressed in mice soon after they have suffered a stroke and that increased TRAF1 expression increases susceptibility to ischaemia-induced apoptosis and brain injury.
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影响因子：
4.8
作者：
Fotin-Mleczek, M;Henkler, F;Wajant, H
通讯作者：
Wajant, H
影响因子：
20.3
作者：
Lin, Fan-Ru;Huang, Shang-Yi;Lin, Kuo-I
通讯作者：
Lin, Kuo-I
影响因子：
6.3
作者：
Gao, YQ;Signore, AP;Chen, J
通讯作者：
Chen, J
DOI：
10.1073/pnas.2336254100
发表时间：
2003-12-09
影响因子：
11.1
作者：
Kuan, CY;Whitmarsh, AJ;Rakic, P
通讯作者：
Rakic, P
影响因子：
14.8
作者：
Degterev, A;Huang, ZH;Yuan, JY
通讯作者：
Yuan, JY