Organization of the corticotectal projection in hamsters with neonatally elevated levels of serotonin in the superior colliculus.
Organization of the corticotectal projection in hamsters with neonatally elevated levels of serotonin in the superior colliculus.
复制标题
新生儿上丘血清素水平升高的仓鼠皮质顶盖投射的组织。
DOI：
10.1016/s0304-3940(99)00813-7
复制
发表时间：
1999
影响因子：
2.5
通讯作者：
Rhoades,RW
中科院分区：
文献类型：
--
作者：
Crnko-Hoppenjans,TA;Yaggie,J;Mooney,RD;Rhoades,RW
A previous study from this laboratory showed that elevated serotonin (5-HT) levels in the hamsters superior colliculus (SC), induced by a single subcutaneous injection of 5,7-dihydroxytryptamine (5,7-DHT) at birth, resulted in an abnormally widespread distribution of the uncrossed retinotectal projection. The present study investigated whether the corticotectal projection in such animals was altered. Adult normal and 5,7-DHT-treated hamsters were injected with horseradish peroxidase (HRP) into occipital cortex and processed for anterograde tracing of corticotectal terminals in the SC. Quantitative analysis showed that normal and 5,7-DHT-treated hamsters were not significantly different in total labeling or in the gradient of labeling density within the SC. These data indicate that corticotectal axons achieve normal terminal fields after neonatal elevation of 5-HT in the SC.
