Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G0 arrest
Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G0 arrest
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DOI：
10.1006/bbrc.1999.1736
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发表时间：
1999-11-30
影响因子：
3.1
通讯作者：
Uchida, T
中科院分区：
文献类型：
--
作者：
Fujimori, F;Takahashi, K;Uchida, T
肽基脯氨酰顺式/反式异构酶PIN 1/Pin 1对于酵母细胞中的有丝分裂进程是必不可少的，并且被假设在哺乳动物细胞中执行相同的作用。为了研究Pin 1在哺乳动物细胞中的功能，我们创建了缺乏Pin 1的小鼠。这些小鼠发育正常。尽管胚胎Pin 1-/-成纤维细胞生长正常，但它们在G（0）停滞后对血清刺激的反应中重新开始增殖的能力明显不足。这些结果表明Pin 1是正常哺乳动物细胞从G（0）停滞到细胞周期进展以及有丝分裂进展所必需的。(C)北京：科学出版社.
The peptidyl prolil cis/trans isomerase Ess1/Pin1 is essential for mitosis progression in yeast cells and is hypothesized to perform the same role in mammalian cells. To investigate the function of Pin1 in mammalian cells, we created mice lacking Pin1. These mice underwent normal development. Although the embryonic Pin1-/- fibroblasts grew normally, they proved significantly deficient in their ability to restart proliferation in response to serum stimulation after G(0) arrest. These results suggest that Pin1 is required for cell cycle progression from G(0) arrest as well as mitosis progression in normal mammalian cells. (C) 1999 Academic Press.