Immunoprivileged Sites: The Testis
Immunoprivileged Sites: The Testis
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DOI：
10.1007/978-1-60761-869-0_29
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Meinhardt, Andreas
中科院分区：
文献类型：
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作者：
Fijak, Monika;Bhushan, Sudhanshu;Meinhardt, Andreas
睾丸是一种免疫豁免组织，其支持移植物的能力证明了这一点，排斥反应最小。免疫赦免对于来自发育中的生殖细胞的新抗原的耐受性是必不可少的，所述生殖细胞在自身耐受性的构建之后出现，但也强加了对病原体和肿瘤细胞提供有效保护的矛盾任务。越来越清楚的是，免疫豁免不能归因于单一因素，如从血睾屏障后面的免疫系统隔离新抗原，而是基于细胞和睾丸生殖功能所必需的因子之间复杂的多方面相互作用和睾丸免疫系统。本文综述了支持细胞、雄激素和选定的白细胞群体在维持免疫赦免及其在睾丸炎性亚群和不育症中的扰动方面的作用。
The testis is an immunological privileged tissue as evidenced by its ability to support grafts with minimal rejection. Immune privilege is essential for the tolerance of neo-antigens from developing germ cells that appear after the constitution of self-tolerance, but imposes the paradoxical task of also providing efficient protection against pathogens and tumor cells. It is becoming increasingly clear that immune privilege cannot be attributed to a single factor such as the sequestration of neo-antigens from the immune system behind the blood testis barrier, but is based on a complex multifaceted interplay between cells and factors that are essential for the reproductive function of the testis and the testicular immune system. This review summarizes the evidence that has accumulated regarding the role of Sertoli cells, androgens, and selected population of leukocytes in the maintenance of immune privilege and its perturbation in testicular inflammatory sub- and infertility.