The Effect of N-6 and N-3 Polyunsaturated Fatty Acids on Hemostasis, Blood Lipids and Blood Pressure
The Effect of N-6 and N-3 Polyunsaturated Fatty Acids on Hemostasis, Blood Lipids and Blood Pressure
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N-6和N-3多不饱和脂肪酸对止血、血脂和血压的影响
DOI：
10.1055/s-0038-1665251
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发表时间：
1983
影响因子：
6.7
通讯作者：
J. Dyerberg
中科院分区：
文献类型：
--
作者：
J. Mortensen;E. Schmidt;A. Nielsen;J. Dyerberg
从海洋油补充到西方饮食的研究中得出的不同结果引发了一项双盲交叉研究的开展，该研究对健康志愿者进行了为期四周的10克鱼油或10克植物油的管理。每种油含有大约。n-3和n-6多不饱和脂肪酸（PUFA）分别为40%。在n-3 PUFA期间，收缩压、血浆总脂、甘油三酯和VLDL浓度显著下降，血浆抗凝血素- iii （AT-III）升高。皮肤出血时间明显增加。相比之下，在n-6 PUFA饲喂期间，AT-III只有升高，但比n-3油饲喂期间更为显著。结论是，在西方饮食中补充n-3多聚脂肪酸油，通常被认为对降低患心血管疾病的风险有益。在这方面，它优于n-6 PUFA，强调有必要采取比目前更有区别的方法来建议膳食中PUFA的富集。
Summary Diverging results from studies of marine oil supplementation to western diets initiated the undertaking of a double-blind crossover study, with administration to healthy volunteers for 4 weeks of either 10 g of fish oil or 10 g of vegetable oil. Each oil containing approx. 40% of n-3 and n-6 polyunsaturated fatty acids (PUFA) respectively. During the n-3 PUFA period, systolic blood pressure, plasma total lipids, triglycerides and VLDL concentrations fell significantly whereas plasma antithrombin-III (AT-III) rose. Cutaneous bleeding time increased significantly. In contrast only AT-III rose during the n-6 PUFA feeding, however, more marked than during the n-3 oil period. It is concluded that a n-3 PUFA oil supplement to the western diet exerts an effect that generally is considered as beneficial in terms of the risk of developing cardiovascular diseases. It is in this respect superior to that of n-6 PUFA, stressing the necessity of a more differentiated approach to advices on dietary PUFA enrichment than presently is exerted.