Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes
Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes
复制标题
DOI：
10.1126/science.1064462
复制
发表时间：
2001-11-09
期刊：
影响因子：
56.9
通讯作者：
McKerrow, JH
中科院分区：
文献类型：
--
作者：
Davies, SJ;Grogan, JL;McKerrow, JH
我们已经确定了Mansoni的生命周期中的替代发育途径。该途径用于免疫缺陷宿主，其中寄生虫无法从宿主免疫系统接收适当的信号。在感染期间的早期阶段，蠕虫发育发生了变化，从而导致延长宿主和寄生虫生存的衰减形式。肝CD4（+）T淋巴细胞种群是寄生虫识别的免疫信号的组成部分。
We have identified an alternate developmental pathway in the life cycle of the trematode pathogen Schistosoma mansoni. This pathway is used in immunodeficient hosts in which the parasite fails to receive appropriate signals from the host immune system. Helminth development is altered at an early stage during infection, resulting in the appearance of attenuated forms that prolong survival of host and parasite. Hepatic CD4(+) T lymphocyte populations are an integral component of the immune signal recognized by the parasite.