Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases.
Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases.
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DOI：
10.1111/jcmm.13038
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发表时间：
2017-05
影响因子：
5.3
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Kander MC;Cui Y;Liu Z
性别差异存在于许多疾病中，在心血管疾病中尤其普遍。男性往往比女性更早患心肌梗死，女性绝经后患心血管疾病的风险增加，这表明雌激素具有心脏保护作用。然而，激素替代疗法并没有降低绝经后妇女心血管疾病的风险;因此，除了雌激素外，可能还涉及其他机制。氧化应激在冠心病等心血管疾病的发生发展中起着重要作用。性别也与氧化应激的差异有关。在生理条件下，女性似乎不太容易受到氧化应激。这可能是由于雌激素的抗氧化特性，NADPH氧化酶活性的性别差异或其他机制尚未确定。这篇综述致力于讨论性别差异的一般条款，然后更详细地检查性别差异与氧化应激和各种相关疾病和潜在的这些差异的可能机制。
Gender differences are present in many diseases and are especially prevalent in cardiovascular disease. Males tend to suffer from myocardial infarctions earlier than females, and a woman's risk of cardiovascular disease increases after menopause, suggesting a cardio‐protective role of estrogen. However, hormone replacement therapy did not decrease the risk of cardiovascular disease in post‐menopausal women; thus, other mechanisms may be involved besides estrogen. Oxidative stress plays an important role in the development of cardiovascular diseases such as coronary artery disease. Gender is also associated with differences in oxidative stress. Under physiological conditions, females appear to be less susceptible to oxidative stress. This may be due to the antioxidant properties of estrogen, gender differences in NADPH‐oxidase activity or other mechanism(s) yet to be defined. This review strives to discuss gender differences in general terms followed by a more detailed examination of gender differences with oxidative stress and various associated diseases and the possible mechanisms underlying these differences.