ATTENUATED INFLUENZA PRODUCED BY EXPERIMENTAL INTRANASAL INOCULATION
ATTENUATED INFLUENZA PRODUCED BY EXPERIMENTAL INTRANASAL INOCULATION
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DOI：
10.1002/jmv.1890030303
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发表时间：
1979-01-01
影响因子：
12.7
通讯作者：
ROTH, FK
中科院分区：
文献类型：
--
作者：
LITTLE, JW;DOUGLAS, RG;ROTH, FK
为了评估自然与实验性流感疾病对肺功能的相对影响，将 43 名正常成年人与 3 次爆发期间记录的非肺炎甲型流感感染进行了比较：1974 年（A/Port Chalmers/74）、1975 年（A/Port Chalmers/74）和 1976 年（A/Victoria/75）与 24 名正常志愿者经鼻接种野生型流感后进行比较 A/英格兰/42/72、A/苏格兰/74 或 A/维多利亚/75。在自然获得性疾病中，观察到小气道功能异常和气道反应性短暂增加。相比之下，在实验诱发的疾病中没有观察到这种功能障碍。该组患者病情较轻，咳嗽持续时间明显较短。
To assess the relative effect of natural vs. experimental influenza illness on pulmonary function, 43 normal adults were compared with documented nonpneumonic influenza A infection during 3 outbreaks: 1974 (A/Port Chalmers/74), 1975 (A/Port Chalmers/74) and 1976 (A/Victoria/75) to 24 normal volunteers following nasal inoculation with wild-type influenza A/England/42/72, A/Scotland/74 or A/Victoria/75. In naturally acquired illness, abnormalities in small airway function and transiently increased airway reactivity were observed. In contrast, no such dysfunction was observed in experimentally induced illness. This group manifested milder illness and significantly shorter duration of cough.