THE EFFECTS OF DORSAL BUNDLE INJECTIONS OF 6‐HYDROXYDOPAMINE ON AVOIDANCE RESPONDING IN RATS
THE EFFECTS OF DORSAL BUNDLE INJECTIONS OF 6‐HYDROXYDOPAMINE ON AVOIDANCE RESPONDING IN RATS
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背束注射6-羟基多巴胺对大鼠回避反应的影响
DOI：
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发表时间：
1978
影响因子：
7.3
通讯作者：
S. Mason
中科院分区：
文献类型：
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作者：
H. Fibiger;S. Mason
1观察了大鼠背侧去甲肾上腺素能神经束内注射6-羟基多巴胺（6-OHDA）对主动回避行为获得、保持和消退的影响。2次6-OHDA注射严重耗尽了所有前脑区域的去甲肾上腺素，但有趣的是，隔膜除外。对前脑各区域的多巴胺浓度无明显影响。3主动回避的获得和保持不受损伤的影响。当非条件刺激（电击）被移除时，可以看到对灭绝的显著抵抗。[4]与其他作者的工作相比，前脑去甲肾上腺素和多巴胺都被耗尽，这表明在两项研究中观察到的消退改变是去甲肾上腺素能效应，而先前发现的获得和保留缺陷起源于多巴胺能。
1 The effects of injection of 6‐hydroxydopamine (6‐OHDA) into the fibres of the dorsal noradrenergic bundle on acquisition, retention and extinction of active avoidance in rats were examined. 2 6‐OHDA injections severely depleted noradrenaline in all forebrain areas assayed, with the interesting exception of the septum. No significant effect on dopamine concentrations in various forebrain regions was found. 3 Acquisition and retention of active avoidance was not altered by the lesion. Marked resistance to extinction was seen when the unconditioned stimulus (shock) was removed. 4 A comparison with work by other authors in which both forebrain noradrenaline and dopamine were depleted suggest that the alteration in extinction seen in both studies is a noradrenergic effect, whereas the deficits in acquisition and retention found previously are dopaminergic in origin.