Single olfactory organ associated with prosencephalic malformation and cyclopia in a Xenopus laevis tadpole.
Single olfactory organ associated with prosencephalic malformation and cyclopia in a Xenopus laevis tadpole.
复制标题
与非洲爪蟾蝌蚪前脑畸形和独眼相关的单一嗅觉器官。
DOI：
10.1016/0006-8993(87)91148-6
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发表时间：
1987
期刊：
影响因子：
2.9
通讯作者：
Graziadei,PP
中科院分区：
文献类型：
--
作者：
Magrassi,L;Graziadei,PP
本文描述了一种具有单一嗅觉器官的非洲爪蟾。在48岁时，端脑严重萎缩，只有嗅纤维终止的区域出现嗅球的细胞结构。在该动物中，中枢神经系统（CNS）仅在视前区后方正常发育。假设间脑起源的嗅纤维终止的区域进行了讨论，根据我们以前的结果嗅基板移植。类比这种情况下，其他畸形（独眼畸形，前脑无裂畸形）在高等脊椎动物和人类之间，需要强调的是一个更精确的解剖描述相关畸形的嗅觉输入。
A cyclopsXenopus laevistadpole with a single olfactory organ is described. At a stage comparable to 48, the telencephalon was severely atrophic and only the region where the olfactory fibres terminated appeared to have the cytoarchitecture of the olfactory bulb. In this animal the central nervous system (CNS) appeared normally developed only posterior to the preoptic area. The hypothesis of a diencephalic origin of the region where the olfactory fibres terminated is discussed in the light of our previous results of olfactory placode transplantation. By analogy between this case and other malformations (cyclopia, holoprosencephaly) in higher vertebrates and humans, the need is emphasized for a more precise anatomical description of the olfactory input in related malformations.