B7x: A widely expressed B7 family member that inhibits T cell activation
B7x: A widely expressed B7 family member that inhibits T cell activation
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DOI：
10.1073/pnas.1434299100
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发表时间：
2003-09-02
影响因子：
11.1
通讯作者：
Allison, JP
中科院分区：
文献类型：
--
作者：
Zang, XX;Loke, P;Allison, JP
B7家族蛋白提供调节T细胞应答的共刺激信号。在这里，我们报告了第三组B7家族相关的T细胞抑制分子与B7家族，B7x的同源物的鉴定。它在免疫细胞、非淋巴组织和一些肿瘤细胞系中表达。B7x抑制CD4（+）和CD8（+）T细胞的细胞周期进程、增殖和细胞因子产生。B7x结合在活化的T细胞上表达的受体，而不是与已知的CD28家族成员不同的静息T细胞。其受体可能是最近发现的一种抑制性分子，B和T淋巴细胞衰减剂。这些研究确定了一种共刺激途径，可能在下调组织特异性自身免疫和抗肿瘤反应中具有独特的功能。
B7 family proteins provide costimulatory signals that regulate T tell responses. Here we report the third set of B7 family-related T cell inhibitory molecules with the identification of a homolog of the B7 family, B7x. It is expressed in immune cells, nonlymphoid tissues, and some tumor cell lines. B7x inhibits cell-cycle progression, proliferation, and cytokine production of both CD4(+) and CD8(+) T cells. B7x binds a receptor that is expressed on activated, but not resting T cells that is distinct from known CD28 family members. Its receptor may be a recently identified inhibitory molecule, B and T lymphocyte attenuator. These studies identify a costimulatory pathway that may have a unique function in down-regulation of tissue-specific autoimmunity and antitumor responses.