HUMAN BORDETELLA-BRONCHISEPTICA INFECTION RELATED TO CONTACT WITH INFECTED ANIMALS - PERSISTENCE OF BACTERIA IN HOST
HUMAN BORDETELLA-BRONCHISEPTICA INFECTION RELATED TO CONTACT WITH INFECTED ANIMALS - PERSISTENCE OF BACTERIA IN HOST
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DOI：
10.1128/jcm.33.8.2002-2006.1995
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发表时间：
1995-08-01
影响因子：
9.4
通讯作者：
GUISO, N
中科院分区：
文献类型：
--
作者：
GUEIRARD, P;WEBER, C;GUISO, N
在2年半的时间里，从79岁患支气管肺炎的妇女身上分离出4次支气管脓毒杆菌。我们通过脉冲场凝胶电泳证实，这种感染与接触被感染的兔子有关。最初的人支杆菌分离株具有通常的支杆菌临床分离株的表型特征；它产生毒素和黏附素，如腺苷酸环化酶-溶血素、丝状血凝素和perpern，并能在小鼠呼吸模型中诱导致死。相比之下，虽然三个连续的人类分离株产生粘附素，但它们不表达腺苷酸环化酶-溶血素，也不能诱导致死。这表明需要腺苷酸环化酶-溶血素来诱导致死性。我们认为分枝杆菌可能在宿主体内持续存在，腺苷酸环化酶-溶血素的表达是感染开始的必要条件，粘附素的表达是持续存在的必要条件。
Within a period of 2 1/2 years, Bordetella bronchiseptica was isolated four times from a 79-year-old woman with bronchopneumonia, We have demonstrated by pulsed-field gel electrophoresis that this infection was related tb contact with infected rabbits. The initial human B. bronchiseptica isolate had a phenotype characteristic of usual B. bronchiseptica clinical isolates; it produced toxin and adhesins, such as adenylate cyclase-hemolysin, filamentous hemagglutinin, and pertactin, and was able to induce lethality in a murine respiratory model. By contrast, although the three successive human isolates produced adhesins, they did not express adenylate cyclase-hemolysin and were unable to induce lethality. This implies that adenylate cyclase-hemolysin is required to induce lethality We suggest that B. bronchispetica may persist in the host, with expression of adenylate cyclase-hemolysin being essential for the initiation of infection and expression of adhesins being essential for persistence.