THE ABSORPTION OF DIETARY PHOSPHORUS AND CALCIUM IN HEMODIALYSIS-PATIENTS
THE ABSORPTION OF DIETARY PHOSPHORUS AND CALCIUM IN HEMODIALYSIS-PATIENTS
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DOI：
10.1038/ki.1986.252
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发表时间：
1986-11-01
影响因子：
19.6
通讯作者：
FORDTRAN, JS
中科院分区：
文献类型：
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作者：
RAMIREZ, JA;EMMETT, M;FORDTRAN, JS
膳食磷的吸收在慢性肾衰竭患者代谢性骨病的发展中起着关键作用。然而，由于透析治疗使代谢平衡研究复杂化，透析患者的磷吸收难以量化。利用最近开发的一种技术，允许测量单餐后膳食成分的净吸收，我们测量了透析患者的磷吸收。主要有以下几点：a)在一顿含约300毫克磷的膳食后，5名血液透析患者（严重缺乏维生素D）的平均磷吸收率仅略低于匹配对照组（186 .+-）。35 vs. 242。30)。b .)透析后患者接受1,25(OH)2-D3治疗后，磷吸收量从186 .+-增加。35到272。16 mg （P < 0.025）。c .)研究了三种含铝抗酸剂对磷吸附的影响；与安慰剂相比，各剂量组对磷的吸收量略有降低（P < 0.01），但两者之间无显著差异。d .)氢氧化铝和碳酸钙各自降低日粮磷吸收的程度大致相同。碳酸钙摄入与钙吸收急剧增加有关。1,25(OH)2-D3对饲料中磷的吸收影响不大，而各种抗酸铝剂和碳酸钙对饲料中磷的吸收也有同样程度的抑制。
Absorption of dietary phosphorus plays a critical role in the development of metabolic bone diseases in patients with chronic renal failure. However, phosphorus absorption is difficult to quantitate in dialysis patients because the dialysis treatments complicate metabolic balance studies. Utilizing a recently developed technique which permits measurement of net absorption of dietary constituents after a single meal, we measured phosphorus absorption in dialysis patients. The following observations were made: A.) Following a meal containing approximately 300 mg phosphorus, mean phosphorus absorption in five hemodialysis patients (with severe vitamin D deficiency) was only slightly less than in matched controls (186 .+-. 35 vs. 242 .+-. 30). B.) After dialysis patients were treated with 1,25(OH)2-D3, phosphorus absorption increased from 186 .+-. 35 to 272 .+-. 16 mg (P < 0.025). C.) The effect of three aluminum containing antacids on phosphorus absorption was studied; each slightly reduced the absorption of phosphorus compared to placebo (P < 0.01), but there was no significant difference between them. D.) Aluminum hydroxide and calcium carbonate each reduced dietary phosphorus absorption to approximately the same extent. Calcium carbonate ingestion was associated with sharply increased calcium absorption. The absorption of dietary phosphorus is influenced only modestly by 1,25(OH)2-D3 and is inhibited to an equal but only modest degree by various aluminum antacids and by calcium carbonate.