Effect of the herbicide glyphosate on liver lipoperoxidation in pregnant rats and their fetuses
Effect of the herbicide glyphosate on liver lipoperoxidation in pregnant rats and their fetuses
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DOI：
10.1016/j.reprotox.2004.09.009
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发表时间：
2005-03-01
影响因子：
3.3
通讯作者：
Giménez, MS
中科院分区：
文献类型：
--
作者：
Beuret, CJ;Zirulnik, F;Giménez, MS
草甘膦是一种芽后除草剂，作用于植物中氨基酸和其他内源代谢物的合成。它通常用于农业、林业和苗圃，用于控制或破坏草本植物。发育和妊娠期间的代谢过程可能对草甘膦引起的变化敏感，例如脂质过氧化。本研究调查了口服 1% 草甘膦对怀孕大鼠及其妊娠 21 天足月胎儿的母体血清和肝脏中的脂过氧化和抗氧化酶系统的影响。结果表明，摄入草甘膦引起的过度脂质过氧化会导致母体和胎儿抗氧化防御系统超载。 (c) 2004 Elsevier Inc. 保留所有权利。
Glyphosate is a post-emergence herbicide that acts on the synthesis of amino acids and other endogenous metabolites in plants. It is commonly used in agriculture, forestry, and nurseries for the control or destruction of herbaceous plants. Metabolic processes during development and pregnancy could be sensitive to changes induced by glyphosate such as lipid peroxidation. The present study has investigated the effects that 1% glyphosate oral exposure has on lipoperoxidation and antioxidant enzyme systems in the maternal serum and liver of pregnant rats and their term fetuses at 21 days of gestation. The results suggest that excessive lipid peroxidation induced with glyphosate ingestion leads to an overload of maternal and fetal antioxidant defense systems. (c) 2004 Elsevier Inc. All rights reserved.