Intramolecular Transfer of Singlet Oxygen.
Intramolecular Transfer of Singlet Oxygen.
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DOI：
10.1021/jacs.5b07848
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发表时间：
2015-10
影响因子：
15
通讯作者：
M. Klaper;T. Linker
中科院分区：
文献类型：
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作者：
M. Klaper;T. Linker
分子内能量转移（FRET）和电子转移（Dexter）是科学界非常感兴趣的问题，并且已经得到了很好的理解。相比之下，单线态氧（(1)O2）的分子内转移是一种活性的短寿命氧，迄今为止还不为人所知。这个过程将非常有趣，因为(1)O2在光动力治疗（PDT）中起着重要作用。在此，我们首次成功地将(1)O2从供体转移到受体。此外，我们发现构象和温度的依赖性与FRET相当。我们为这种转移的分子内特征提供了一些证据，包括竞争实验。我们的研究不仅从理论和机制的角度来看是有趣的，而且对于新的(1)氧供体的设计和在PDT中的应用也是有趣的。
The intramolecular transfer of energy (FRET) and electrons (Dexter) are of great interest for the scientific community and are well-understood. In contrast, the intramolecular transfer of singlet oxygen ((1)O2), a reactive and short-lived oxygen species, has until now been unknown. This process would be very interesting because (1)O2 plays an important role in photodynamic therapy (PDT). Herein, we present the first successful intramolecular transfer of (1)O2 from a donor to acceptor. Also, we found a dependence of conformation and temperature comparable with those of FRET. We provide several pieces of evidence for the intramolecular character of this transfer, including competition experiments. Our studies should be interesting not only from the theoretical and mechanistic point of view but also for the design of new (1)O2 donors and applications in PDT.