Designed extension of studies based on conditional power
Designed extension of studies based on conditional power
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DOI：
10.2307/2533262
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发表时间：
1995-12-01
期刊：
影响因子：
1.9
通讯作者：
Hunsberger, SA
中科院分区：
文献类型：
--
作者：
Proschan, MA;Hunsberger, SA
我们提出了一种灵活的方法，扩展研究的基础上条件的权力。当计划结束时的p值较小但不具有统计学显著性时，扩展的可能性已纳入研究设计。计划结束时的治疗差异的显著性用于确定所需的额外观察结果的数量以及累积这些额外观察结果后所需使用的临界值。因此，可将其视为两阶段程序。即使在第1阶段观察到的治疗差异用于决策，I类错误率也受到保护。
We propose a flexible method of extending a study based on conditional power. The possibility for extension when the p value at the planned end is small but not statistically significant is built in to the design of the study. The significance of the treatment difference at the planned end is used to determine the number of additional observations needed and the critical value necessary for use after accruing those additional observations. It may therefore be thought of as a two-stage procedure. Even though the observed treatment difference at stage 1 is used to make decisions, the Type I error rate is protected.