The Obstetric Origins of Health for a Lifetime
The Obstetric Origins of Health for a Lifetime
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DOI：
10.1097/grf.0b013e31829cb9ca
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发表时间：
2013-09-01
影响因子：
1.5
通讯作者：
Thornburg, Kent L.
中科院分区：
文献类型：
--
作者：
Barker, David J. P.;Thornburg, Kent L.
有一个新的发展模式的起源广泛的慢性疾病。在这种模式下，要确定的原因与胎儿胎盘发育的正常变化有关。这些变异被认为会导致婴儿营养供应的变化，从而永久改变基因表达，这一过程被称为编程。根据发育模型的变化，发育过程中的一些关键系统的功能与疾病有关，包括免疫系统，抗氧化防御，炎症反应以及干细胞的数量和质量。
There is a new developmental model for the origins of a wide range of chronic diseases. Under this model the causes to be identified are linked to normal variations in fetoplacental development. These variations are thought to lead to variations in the supply of nutrients to the baby that permanently alter gene expression, a process known as programming. According to the developmental model variations in the processes of development program the function of a few key systems that are linked to disease, including the immune system, antioxidant defenses, inflammatory responses, and the number and quality of stem cells.