Carnosol Alleviates Collagen-Induced Arthritis by Inhibiting Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T Cells.
Carnosol Alleviates Collagen-Induced Arthritis by Inhibiting Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T Cells.
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DOI：
10.1155/2023/1179973
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发表时间：
2023
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目前的方法是无法治愈的类风湿性关节炎（RA）。调节性T（Treg）细胞和辅助性T细胞（Th 1和Th 17）在控制以炎性细胞浸润和骨破坏为特征的RA过程中至关重要。鼠尾草酚是一种邻位二酚类二萜，在传统医学中广泛应用于多种自身免疫性和炎症性疾病的治疗。在此，我们表明给予鼠尾草酚显著减轻了胶原诱导的关节炎（CIA）模型的严重程度，具有降低的临床评分和炎症减轻。在细胞机制上，鼠尾草酚在体外和体内抑制Th 17细胞分化并维持Treg细胞抑制功能。同时，它还抑制Treg细胞在炎症环境下转分化为Th 17细胞。此外，鼠尾草酚可能通过限制IL-6 R（CD 126）表达来调节Th 17和Treg细胞的功能。以上结果提示，鼠尾草酚可通过抑制Th 17细胞分化，维持Treg细胞的稳定性，从而减轻CIA的严重程度。鼠尾草酚的给药可作为RA患者的潜在治疗方法。
Current approaches are incurable for rheumatoid arthritis (RA). Regulatory T (Treg) cells and T helper cells (Th1 and Th17) are crucial in controlling the process of RA, which is characterized by inflammatory cell infiltration and bone destruction. Carnosol is an orthodiphenolic diterpene that has been extensively applied in traditional medicine for the treatment of multiple autoimmune and inflammatory diseases. Herein, we indicate that administration of carnosol dramatically alleviated the severity of collagen-induced arthritis (CIA) model with a decreased clinical score and inflammation reduction. Cellular mechanistically, carnosol inhibits the Th17 cell differentiation and maintains Treg cell suppressive function in vitro and in vivo. Meanwhile, it also restrains Treg cells from transdifferentiation into Th17 cells under inflammatory milieu. Furthermore, carnosol modulates the function of Th17 and Treg cells possibly via limiting IL-6R (CD126) expression. Collectively, our results suggest that carnosol can alleviate the severity of CIA via hiding Th17 cell differentiation and maintain the stability of Treg cells. Administration of carnosol can be applied as a potential therapy for patients with RA.