Hydroxylated PCB metabolites and PCBs in serum from pregnant Faroese women
Hydroxylated PCB metabolites and PCBs in serum from pregnant Faroese women
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DOI：
10.1289/ehp.02110895
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发表时间：
2002-09-01
影响因子：
10.4
通讯作者：
Bergman, Å
中科院分区：
文献类型：
--
作者：
Fängström, B;Athanasiadou, M;Bergman, Å
在北大西洋的法罗群岛，传统的饮食包括领航鲸肉和鲸脂以及其他海洋食物。多脂鱼类和哺乳动物的脂肪可能含有高浓度的有机卤素物质。据报告，法罗群岛的OHSS水平升高，首次记录于1987年获得的母乳样本中。本研究的目的是确定羟化多氯联苯（OH-PCBs）和多氯联苯（PCBs）的浓度从怀孕的法罗群岛妇女已知不同的饮食习惯的血清样本。高浓度的OH-PCB和PCB被发现在部分分析的人血清样品中，和相对OH-PCB和PCB同系物的分布是类似的观察到的其他地方。在所分析的血清样本中，OH-PCB和PCB的最低和最高浓度之间的跨度很大，范围分别为19- 1，800纳克/克脂重和150- 22，000纳克/克脂重。SigmaOH-PCB/SigmaPCB的比例平均约为10%，变化不大。4-羟基-2，2 '，3，4'，5，5 '，6-七氯联苯是所有分析样品中最丰富的OH-PCB代谢物，其他四种OH-PCB同系物是血清中的主要代谢物。超过25个额外的OH-多氯联苯。这项研究证实，远离其来源的人群或地区存在高浓度的有机卤素物质。
In the Faroe Islands in the North Atlantic, the traditional diet includes pilot whale meat and blubber and other marine food. Fatty fish and blubber of mammals may contain high concentrations of organohalogen substances (OHSs). Elevated levels of OHSs have been reported from the Faroe islands, first documented in breast milk samples obtained in 1987. The aim of this study was to determine the concentrations of hydroxylated polychlorinated biphenyls (OH-PCBs) and polychlorinated biphenyls (PCBs) in serum samples from pregnant Faroese women known to differ in their dietary habits. High concentrations of OH-PCBs and PCBs were found in part of the human serum samples analyzed, and the relative OH-PCB and PCB congener distributions were similar to those observed elsewhere. There was a wide span between the lowest and highest OH-PCB and PCB concentrations in the serum samples analyzed, with ranges of 19-1,800 ng/g lipid weight (lw) and 150-22,000 ng/g lw, respectively. The ratio of SigmaOH-PCB/SigmaPCB averaged about 10% and varied little. 4-Hydroxy-2,2',3,4',5,5',6-heptachlorobiphenyl was the most abundant OH-PCB metabolite in all samples analyzed, with four other OH-PCB congeners as dominating metabolites in the serum. More than 25 additional OH-PCBs were indicated. This study confirms the presence of high concentrations of organohalogen substances in populations or areas far removed from their sources.