Factors that affect genetic interaction during mixed infection with temperature-sensitive mutants of simian rotavirus SA11.
Factors that affect genetic interaction during mixed infection with temperature-sensitive mutants of simian rotavirus SA11.
复制标题
猿轮状病毒 SA11 温度敏感突变体混合感染时影响遗传相互作用的因素。
DOI：
10.1016/0042-6822(83)90374-4
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发表时间：
1983
期刊：
影响因子：
3.7
通讯作者：
Ramig,RF
中科院分区：
文献类型：
--
作者：
Ramig,RF
研究了猴轮状病毒SA 11温度敏感突变体混合感染过程中影响遗传相互作用的许多因素。(1)重组频率（RF）的统计分析表明，（a）RF中观察到的变异性与实验条件的变化无关，（B）无法绘制突变的线性图。(2)重组子的野生型表型在传代时是稳定的。(3)子代病毒或杂合子代病毒颗粒的聚集体对观察到的RF没有显著贡献。(4)RF增加与多重感染平行。(5)最大或接近最大的RF在最早的时间获得显著的重组体可以被检测到。(6)在非允许的温度下，脱水是有效的。(7)互补没有发生或效率低下。(8)来自所有重组组的突变体干扰野生型病毒在允许和非允许温度下的生长。
A number of factors that affect genetic interaction during mixed infection with temperature-sensitive mutants of simian rotavirus SA11 have been examined. (1) Statistical analyses of recombination frequency (RF) indicated that (a) the variability noted in RF was not related to variations in experimental conditions and (b) a linear map of the mutations could not be drawn. (2) The wild phenotype of recombinant progeny was stable on passage. (3) Aggregates of progeny virus or heterozygous progeny virus particles did not contribute significantly to the observed RF. (4) RF increased in parallel with multiplicity of infection. (5) A maximal, or near maximal, RF was obtained at the earliest time significant recombinants could be detected. (6) Recombination was efficient at nonpermissive temperature. (7) Complementation did not occur or was inefficient. (8) Mutants from all recombination groups interfered with the growth of wild-type virus at both permissive and nonpermissive temperatures.