MTHFR c.677C>T polymorphism as an independent predictor of peak bone mass in Danish men -: from the Odense Androgen Study
MTHFR c.677C>T polymorphism as an independent predictor of peak bone mass in Danish men -: from the Odense Androgen Study
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DOI：
10.1016/j.bone.2005.08.005
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发表时间：
2006-02-01
期刊：
影响因子：
4.1
通讯作者：
Brixen, K
中科院分区：
文献类型：
--
作者：
Abrahamsen, B;Jorgensen, HL;Brixen, K
MTHFR c.677C > T多态性已被证明对中年至老年女性和男性的骨骼健康具有显著影响。尽管关于MTHFR遗传学和同型半胱氨酸水平与骨折之间的关联的数据越来越多，但MTHFR c.677C > T基因型是否影响青年骨矿物质增加或成年骨丢失仍然未知。这项横断面研究的目的是检查这种常见的等位基因多态性对峰值骨量和骨转换的影响。我们对780名健康的丹麦男性进行了MTHFR基因分型，年龄在20到29岁之间，参与了Odense雄激素研究。使用Hologic QDR-4500密度计测量脊柱、髋部和全身的BMD。基因型频率符合Hardy-Weinberg平衡。脊柱骨密度与基因型显著相关，每个T等位基因拷贝的骨密度降低0.20 SD。这些影响与年龄、BMI、吸烟和血清维生素D和IGF-I水平无关。与髋部及全身BMD的相关性均无统计学意义。MTHFR基因型与骨转换标志物1-CTP、骨特异性碱性磷酸酶和骨钙素无相关性。总之，在25岁的男性中，这种常见的多态性对腰椎的骨骼有显著的影响。(c)2005年由Elsevier Inc.出版
The MTHFR c.677C > T polymorphism has been shown to have significant effects on skeletal health in middle-aged to elderly women and men. Despite an accumulating amount of data on MTHFR genetics and the association between homocysteine levels and fracture, it remains unknown if MTHFR c.677C > T genotype affects bone mineral accretion in Youth or bone loss in adulthood. The purpose of this cross-sectional study was to examine the effects of this common allelic polymorphism on peak bone mass and bone turnover. We performed MTHFR genotyping in 780 healthy Danish men, aged 20 to 29 years, participating in the Odense Androgen Study. BMD at the spine, hip and whole-body was measured using a Hologic QDR-4500 densitometer. Genotype frequencies were compatible with Hardy-Weinberg equilibrium. Spine BMD was significantly associated with genotype, with a decrease in BMD of 0.20 SD for each copy of the T-allele. Effects were independent of age, BMI, smoking and serum levels of vitamin D and IGF-I. Associations with BMD of the hip and whole body were short of statistical significance. MTHFR genotype showed no association with the bone turnover markers 1-CTP, bone specific alkaline phosphatase or osteocalcin. In conclusion, significant skeletal effects of this common polymorphism were present at the lumbar spine in men at the age of 25 years. (c) 2005 Published by Elsevier Inc.