Autonomic and psychic effects of yohimbine hydrochloride
Autonomic and psychic effects of yohimbine hydrochloride
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盐酸育亨宾的自主神经和精神作用
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
S. Gershon
中科院分区：
文献类型：
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作者：
G. Holmberg;S. Gershon
育亨宾以0.5mg/kg的剂量给51名男性精神病患者和9名正常志愿者服用，产生胆碱能和肾上腺素能型自主神经效应和模拟焦虑状态的精神效应。这两种对育亨宾的反应程度与基本的情绪反应水平高度相关，中枢神经系统抑制剂异戊巴比妥和Ro 5-0690降低了对育亨宾的反应程度，而中枢神经系统兴奋剂丙咪嗪和肾上腺素增强了育亨宾的作用。育亨宾在这里使用的剂量对注射的肾上腺素没有任何阻断作用。育亨宾在一些精神分裂症病例中产生精神病图片的激活。育亨宾是一种有希望用作自主神经试验药物的化合物。
SummaryYohimbine in a dose of 0.5 mg/kg has been given to 51 male mental hospital subjects and nine normal volunteers.It has produced both cholinergic and adrenergic-type autonomic effects and psychic effects simulating an anxiety state. The degree of both these responses to yohimbine correlates highly with the basic level of emotional reactivity.Central nervous system depressants, amobarbital and Ro 5–0690, reduced the degree of response to yohimbine, whilst the CNS stimulants imipramine and epinephrine potentiated the yohimbine effect. Yohimbine in the dosage here employed did not have any blocking effect against injected epinephrine.Activation of the psychotic picture was produced by yohimbine in some schizophrenic cases.Yohimbine is a promising compound for use as an autonomic test drug.