Cardiometabolic risk in impaired fasting glucose and impaired glucose tolerance - The atherosclerosis risk in communities study
Cardiometabolic risk in impaired fasting glucose and impaired glucose tolerance - The atherosclerosis risk in communities study
复制标题
DOI：
10.2337/dc06-1457
复制
发表时间：
2007-02-01
期刊：
影响因子：
16.2
通讯作者：
Ballantyne, Christie M.
中科院分区：
文献类型：
--
作者：
Pankow, James S.;Kwan, David K.;Ballantyne, Christie M.
目的-我们比较和对比心血管疾病（CVD）的危险因素，亚临床表现的CVD，冠心病事件（CHD），和所有原因的死亡率类别受损的血糖调节在nondiabeticindividual.RESEARCH设计和方法-这项研究包括6,888名参与者年龄在52-75岁谁没有糖尿病或CVD的历史。全因死亡率和冠心病事件的中位数为6.3年的随访确定。结果-空腹和挑战后血糖受损之间的协议是穷人：3，048例受试者（44%）既没有空腹血糖受损（IFG），也没有糖耐量受损（IGT），1，690例（25%）有孤立的IFG，1，000例（14%）有孤立的IGT，1例（14%）有单独的IGT，149例（17%）同时存在IFG和IGT。校正年龄、性别、种族和研究中心后，与单纯IGT患者相比，单纯IFG患者更可能吸烟、饮酒，平均BMI、腰围、LDL胆固醇和空腹胰岛素更高，HDL胆固醇更低，而单纯IGT患者的平均甘油三酯、收缩压和白色细胞计数更高。孤立IFG和孤立IGT.CONCLUSIONS的措施，亚临床心血管疾病和全因死亡率和冠心病事件的发生率是相似的，既不是孤立IFG也不是孤立IGT与更不利的心血管疾病的风险概况。
OBJECTIVE - We compared and contrasted cardiovascular disease (CVD) risk factors, subclinical manifestations of CVD, incident coronary heart disease (CHD), and all-cause mortality by categories of impaired glucose regulation in nondiabetic individuals.RESEARCH DESIGN AND METHODS - The study included 6,888 participants aged 52-75 years who had no history of diabetes or CVD. All-cause mortality and incident CHD were ascertained over a median of 6.3 years of follow-up.RESULTS - Agreement between fasting and postchallenge glucose impairment was poor: 3,048 subjects (44%) had neither impaired fasting glucose (IFG) nor impaired glucose tolerance (IGT), 1,690 (25%) had isolated IFG, 1,000 (14%) had isolated IGT, and 1,149 (17%) had both IFG and IGT. After adjustment for age, sex, race, and center, subjects with isolated IFG were more likely to smoke, consume alcohol, and had higher mean BMI, waist circumference, LDL cholesterol, and fasting insulin and lower HDL cholesterol than those with isolated IGT, while subjects with isolated IGT had higher mean triglycerides, systolic blood pressure, and white cell counts. Measures of subclinical CVD and rates of all-cause mortality and incident CHD were similar in isolated IFG and isolated IGT.CONCLUSIONS - Neither isolated IFG nor isolated IGT was associated with a more adverse CVD risk profile.