Misaligned feeding impairs memories
Misaligned feeding impairs memories
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DOI：
10.7554/elife.09460
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发表时间：
2015-12-10
期刊：
影响因子：
7.7
通讯作者：
Colwell, Christopher S.
中科院分区：
文献类型：
--
作者：
Loh, Dawn H.;Jami, Shekib A.;Colwell, Christopher S.
强健的睡眠/觉醒节律对健康和认知功能很重要。不幸的是，许多人生活在一个环境中，他们的昼夜节律系统受到不适当的用餐或工作时间的挑战。在这里，我们安排食物进入睡眠时间，并检查对小鼠学习和记忆的影响。在这些条件下，我们证明了主起搏器，视交叉上核（SCN）的分子钟，是不变的，而在海马体中的分子钟是同步的食物供应的时间。这种慢性昼夜节律失调导致海马长时程增强和总CREB表达减少。重要的是，这种错误的喂食时间导致了依赖于露营的学习和记忆的严重缺陷。我们的研究结果表明，吃饭的时间对海马体的生理和学习行为有深远的影响。
Robust sleep/wake rhythms are important for health and cognitive function. Unfortunately, many people are living in an environment where their circadian system is challenged by inappropriate meal- or work-times. Here we scheduled food access to the sleep time and examined the impact on learning and memory in mice. Under these conditions, we demonstrate that the molecular clock in the master pacemaker, the suprachiasmatic nucleus (SCN), is unaltered while the molecular clock in the hippocampus is synchronized by the timing of food availability. This chronic circadian misalignment causes reduced hippocampal long term potentiation and total CREB expression. Importantly this mis-timed feeding resulted in dramatic deficits in hippocampal-dependent learning and memory. Our findings suggest that the timing of meals have far-reaching effects on hippocampal physiology and learned behaviour.