Therapeutic potential of resveratrol in Alzheimer's disease.
Therapeutic potential of resveratrol in Alzheimer's disease.
复制标题
白藜芦醇在阿尔茨海默氏病中的治疗潜力。
DOI：
10.1186/1471-2202-9-s2-s6
复制
发表时间：
2008-12-03
期刊：
影响因子：
2.4
通讯作者：
Marambaud P
中科院分区：
文献类型：
--
作者：
Vingtdeux V;Dreses-Werringloer U;Zhao H;Davies P;Marambaud P
一些流行病学研究表明，适量饮用红葡萄酒与痴呆症和阿尔茨海默病的发病率较低有关。红葡萄酒富含具有潜在神经保护活性的抗氧化多酚。尽管对这些多酚的生物利用度持怀疑态度，但体内数据已经清楚地证明了天然多酚白藜芦醇在啮齿动物模型中对压力和疾病的神经保护特性。此外，最近在细胞培养和动物模型中的工作揭示了白藜芦醇摄入对阿尔茨海默病神经退行性过程的有益作用可能涉及的分子机制。
Several epidemiological studies indicate that moderate consumption of red wine is associated with a lower incidence of dementia and Alzheimer's disease. Red wine is enriched in antioxidant polyphenols with potential neuroprotective activities. Despite scepticism concerning the bioavailability of these polyphenols, in vivo data have clearly demonstrated the neuroprotective properties of the naturally occurring polyphenol resveratrol in rodent models for stress and diseases. Furthermore, recent work in cell cultures and animal models has shed light on the molecular mechanisms potentially involved in the beneficial effects of resveratrol intake against the neurodegenerative process in Alzheimer's disease.