Effects of cell cycle noise on excitable gene circuits.
Effects of cell cycle noise on excitable gene circuits.
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DOI：
10.1088/1478-3975/13/6/066007
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发表时间：
2016-11-30
期刊：
影响因子：
2
通讯作者：
Ott W
中科院分区：
文献类型：
--
作者：
Veliz-Cuba A;Gupta C;Bennett MR;Josić K;Ott W
我们评估细胞周期噪声对基因电路动力学的影响。对于遗传开关和可兴奋电路，我们发现亚稳态之间的转换最有可能发生在细胞分裂后，这种浓度效应在转录延迟的存在下加剧。我们用一个三态随机模型解释了这种浓度效应。对于遗传振荡器，我们量化的时间相关性的子细胞诱导细胞分裂。为了准确量化基因网络中的噪声源，必须正确捕获时间相关性。
We assess the impact of cell cycle noise on gene circuit dynamics. For bistable genetic switches and excitable circuits, we find that transitions between metastable states most likely occur just after cell division and that this concentration effect intensifies in the presence of transcriptional delay. We explain this concentration effect with a 3-states stochastic model. For genetic oscillators, we quantify the temporal correlations between daughter cells induced by cell division. Temporal correlations must be captured properly in order to accurately quantify noise sources within gene networks.